Pippalla R S, Chinburapa V, Duval R, Akula R S
College of Pharmacy and Pharmaceutical Sciences, Howard University, Washington, DC, USA.
J Clin Pharm Ther. 1997 Oct-Dec;22(5-6):357-69. doi: 10.1111/j.1365-2710.1997.tb00019.x.
(i) To assess quality of life (QoL) profiles in hypertensive geriatrics with SF-36; (ii) to assess the compliance of geriatrics to medications; (iii) to estimate clinical outcomes (reduction in systolic and diastolic blood pressure); (iv) to assess life satisfaction and (v) to explore the interrelationships of QoL, compliance, clinical outcomes and life satisfaction in hypertensive geriatrics.
Fifty-nine hypertensive geriatric patients in cardiology and 65 Plus clinics in West Virginia Hospitals were studied.
Age showed a significant negative correlation with physical functioning (r = 0.339, P< or =0.0127) and physical role (r=0.335, P< or =0.0148). The physical role facet of SF-36 is correlated with life satisfaction in geriatrics (r = 0.316, P < or =0.0219). A regression analysis (backward stepwise) not including bodily pain (BP) and general health (GH) resulted in a model explaining 22.3% of variance (n = 54, F = 2.252, P < or = 0.0543). Physical role (P < or = 0.0084) and mental health facets (P< or = 0.0184) of SF-36 emerged as the predictors of life satisfaction in elderly hypertensive patients. Emotional role functioning (P < or = 0.0257) and social functioning (P < or = 0.0033) scores predicted levels of diastolic blood pressure in elderly hypertensive patients. However, all eight concepts of SF-36 failed to predict compliance behaviour in geriatrics (n = 53, P < or = 0.6913, R2= 0.110).
(i)使用SF-36评估老年高血压患者的生活质量(QoL)概况;(ii)评估老年患者的药物依从性;(iii)估计临床结果(收缩压和舒张压降低);(iv)评估生活满意度;(v)探讨老年高血压患者生活质量、依从性、临床结果和生活满意度之间的相互关系。
对西弗吉尼亚医院心脏病科和65岁以上诊所的59名老年高血压患者进行了研究。
年龄与身体功能(r = 0.339,P≤0.0127)和身体角色(r = 0.335,P≤0.0148)呈显著负相关。SF-36的身体角色方面与老年患者的生活满意度相关(r = 0.316,P≤0.0219)。一项不包括身体疼痛(BP)和总体健康(GH)的回归分析(向后逐步回归)得出一个模型,该模型解释了22.3%的方差(n = 54,F = 2.252,P≤0.0543)。SF-36的身体角色(P≤0.0084)和心理健康方面(P≤0.0184)成为老年高血压患者生活满意度的预测因素。情绪角色功能(P≤0.0257)和社会功能(P≤0.0033)得分预测了老年高血压患者的舒张压水平。然而,SF-36的所有八个概念均未能预测老年患者的依从行为(n = 53,P≤0.6913,R2 = 0.110)。