治疗依从性与健康相关生活质量相关吗？一项横断面研究的结果。
Does treatment adherence correlates with health related quality of life? Findings from a cross sectional study.
机构信息
Department of Pharmacy, University of Baluchistan, Quetta, Pakistan.
出版信息
BMC Public Health. 2012 Apr 30;12:318. doi: 10.1186/1471-2458-12-318.
BACKGROUND
Although medication adherence and health-related quality of life (HRQoL) are two different outcome measures, it is believed that adherence to medication leads to an improvement in overall HRQoL. The study aimed to evaluate the association between medication adherence and HRQoL.
METHODS
A questionnaire-based cross-sectional study design was undertaken with hypertension patients attending public hospitals in Quetta city, Pakistan. HRQoL was measured by Euroqol EQ-5D. Medication adherence was assessed by the Drug Attitude Inventory. Descriptive statistics was used to tabulate demographic and disease-related information. Spearmans correlation was used to assess the association between the study variables. All analysis was performed using SPSS 17.0.
RESULTS
Among 385 study patients, the mean age (SD) was 39.02 (6.59), with 68.8% of males dominating the entire cohort. The mean (SD) duration of hypertension was 3.010.939years. Forty percent (n=154) had a bachelors degree level of education with 34.8% (n=134) working in the private sector. A negative and weak correlation (0.77) between medication adherence and EQ-5D was reported. In addition, a negative weak correlation (0.120) was observed among medication adherence and EQ-VAS.
CONCLUSIONS
Correlations among the study variables were negligible and negative. Hence, there is no apparent relationship between the variables.
背景
尽管药物依从性和健康相关生活质量（HRQoL）是两种不同的结果衡量指标，但人们相信药物依从性会导致整体 HRQoL 的提高。本研究旨在评估药物依从性与 HRQoL 之间的关系。
方法
采用基于问卷的横断面研究设计，对巴基斯坦奎达市公立医院的高血压患者进行研究。使用 EuroQol EQ-5D 来衡量 HRQoL。药物依从性通过药物态度量表来评估。使用描述性统计来列出人口统计学和疾病相关信息。Spearmans 相关分析用于评估研究变量之间的关联。所有分析均使用 SPSS 17.0 进行。
结果
在 385 名研究患者中，平均年龄（标准差）为 39.02（6.59），其中 68.8%的患者为男性。高血压的平均（标准差）病程为 3.01±0.939 年。40%（n=154）的患者具有学士学位水平的教育程度，其中 34.8%（n=134）在私营部门工作。报告药物依从性与 EQ-5D 之间存在负相关和弱相关（0.77）。此外，还观察到药物依从性与 EQ-VAS 之间存在负相关和弱相关（0.120）。
结论
研究变量之间的相关性微不足道且为负相关。因此，这些变量之间没有明显的关系。
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