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Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways.二十一世纪的毒性测试:基于细胞内毒性通路的扰动来定义新的风险评估方法。
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本文引用的文献

1
Toxicity testing in the 21st century: bringing the vision to life.21世纪的毒性测试:将愿景变为现实。
Toxicol Sci. 2009 Feb;107(2):324-30. doi: 10.1093/toxsci/kfn255. Epub 2008 Dec 12.
2
Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals.用于考量动物肿瘤假定作用模式与人类相关性的框架的最新进展。
Environ Mol Mutagen. 2008 Mar;49(2):110-6. doi: 10.1002/em.20369.
3
Risk characterisation of chemicals in food and diet.食品及饮食中化学物质的风险特征描述。
Food Chem Toxicol. 2003 Sep;41(9):1211-71. doi: 10.1016/s0278-6915(03)00064-4.
4
The role of time as a quantifiable variable of toxicity and the experimental conditions when Haber's c x t product can be observed: implications for therapeutics.
J Pharmacol Exp Ther. 2001 Mar;296(3):663-8.

Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? ...or a new edition of "the Red Book"?

作者信息

Meek Bette, Doull John

机构信息

McLaughlin Institute for Population Health Risk Assessment, University of Ottawa, Tunney's Pasture, Address Locator 0801C2, Ottawa K1A 0L2, Ontario, Canada.

出版信息

Toxicol Sci. 2009 Mar;108(1):19-21. doi: 10.1093/toxsci/kfp008. Epub 2009 Jan 23.

DOI:10.1093/toxsci/kfp008
PMID:19168570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2644399/
Abstract
摘要