前体脑源性神经营养因子何去何从？ - Suppr | 超能文献

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1

Whither proBDNF?前体脑源性神经营养因子何去何从？

Nat Neurosci. 2009 Feb;12(2):105-6. doi: 10.1038/nn0209-105.

2

Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin.血清素对大脑中脑源性神经营养因子（BDNF）及其前体proBDNF的调节作用。

Eur Arch Psychiatry Clin Neurosci. 2016 Apr;266(3):195-7. doi: 10.1007/s00406-016-0682-9.

3

Hippocampal proBDNF facilitates place learning strategy associated with neural activity in rats.海马体 proBDNF 促进了与大鼠神经活动相关的位置学习策略。

Brain Struct Funct. 2018 Dec;223(9):4099-4113. doi: 10.1007/s00429-018-1742-x. Epub 2018 Aug 27.

4

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.前脑源性神经营养因子通过激活p75神经营养因子受体（p75NTR）和sortilin的受体复合物诱导神经元凋亡。

J Neurosci. 2005 Jun 1;25(22):5455-63. doi: 10.1523/JNEUROSCI.5123-04.2005.

5

Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons.培养的小脑颗粒神经元中前体 BDNF 和成熟 BDNF 的不同信号通路。

Neurosci Lett. 2010 Apr 12;473(3):229-32. doi: 10.1016/j.neulet.2010.02.055. Epub 2010 Feb 26.

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Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure.塑造神经元：成熟和 proBDNF 信号对神经元结构的长程和短程影响。

Neuropharmacology. 2014 Jan;76 Pt C(0 0):603-9. doi: 10.1016/j.neuropharm.2013.04.054. Epub 2013 May 7.

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BDNF as an anterophin; a novel neurotrophic relationship between brain neurons.脑源性神经营养因子作为一种前向亲素；脑神经元之间一种新的神经营养关系。

Trends Neurosci. 2001 Dec;24(12):683-4; discussion 684-5. doi: 10.1016/s0166-2236(00)01955-x.

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Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF).人源Val66而非Met66前脑源性神经营养因子（proBDNF）激活突触减弱通路。

Pharmacol Res. 2016 Feb;104:97-107. doi: 10.1016/j.phrs.2015.12.008. Epub 2015 Dec 11.

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Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression.前体脑源性神经营养因子（proBDNF）和脑源性神经营养因子（BDNF）在抑郁症动物模型诱导的树突棘可塑性和抑郁样行为中的作用。

Brain Res. 2017 May 15;1663:29-37. doi: 10.1016/j.brainres.2017.02.020. Epub 2017 Mar 8.

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Injection of Anti-proBDNF in Anterior Cingulate Cortex (ACC) Reverses Chronic Stress-Induced Adverse Mood Behaviors in Mice.在前扣带回皮质（ACC）注射抗前脑源性神经营养因子（proBDNF）可逆转慢性应激诱导的小鼠不良情绪行为。

Neurotox Res. 2017 Feb;31(2):298-308. doi: 10.1007/s12640-016-9687-4. Epub 2016 Dec 12.

引用本文的文献

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Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury.与骨科损伤相比，小儿创伤性脑损伤后观察到脑源性神经营养因子基因的差异DNA甲基化。

medRxiv. 2025 Jun 16:2025.06.16.25329571. doi: 10.1101/2025.06.16.25329571.

2

Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle.五苓散在治疗溃疡性结肠炎合并抑郁症中的应用作为一种新的治疗原则。

World J Gastroenterol. 2025 Jun 21;31(23):106538. doi: 10.3748/wjg.v31.i23.106538.

3

Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression.

本文引用的文献

1

Neuronal release of proBDNF.脑源性神经营因子前体的神经元释放。

Nat Neurosci. 2009 Feb;12(2):113-5. doi: 10.1038/nn.2244. Epub 2009 Jan 11.

2

Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons.长3'UTR脑源性神经营养因子mRNA在海马神经元脊柱形态和突触可塑性中的独特作用。

Cell. 2008 Jul 11;134(1):175-87. doi: 10.1016/j.cell.2008.05.045.

3

Activity-dependent expression of brain-derived neurotrophic factor in dendrites: facts and open questions.脑源性神经营养因子在树突中的活性依赖性表达：事实与未解决的问题。