Flynn Michael R, Susi Pam
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599-7431, USA.
Int J Hyg Environ Health. 2009 Sep;212(5):459-69. doi: 10.1016/j.ijheh.2008.12.003. Epub 2009 Jan 31.
Exposure to manganese dusts and fumes may cause a clinical neurological syndrome called manganism. Welders are frequently exposed to manganese-containing fumes generated by electric arcs and thermal torches. This paper reviews studies on the association between exposure to such welding fumes and neurological disease. Using the IRSST expert panel criteria, 78 cases of probable/possible, and 19 additional cases of possible occupational manganism were identified in the literature among manganese-exposed workers involved in welding processes. Epidemiological evidence linking welding exposures to Parkinson's disease is still controversial. Although more research is needed to clarify the risks of neurological impairment from welding, control measures including ventilation and adequate respiratory protection, should be implemented to minimize welding fume exposures. The significance of fume transport into the central nervous system via the olfactory nerve, which by-passes the blood-brain barrier, also needs to be assessed.
接触锰尘和锰烟可能会引发一种名为锰中毒的临床神经综合征。焊工经常接触电弧和热熔炬产生的含锰烟雾。本文综述了关于接触此类焊接烟雾与神经疾病之间关联的研究。根据魁北克职业病防治研究所专家小组的标准，在涉及焊接工艺的锰接触工人的文献中，确定了78例可能/疑似病例，以及另外19例可能的职业性锰中毒病例。将焊接接触与帕金森病联系起来的流行病学证据仍存在争议。尽管需要更多研究来阐明焊接导致神经损伤的风险，但应实施包括通风和适当呼吸防护在内的控制措施，以尽量减少焊接烟雾暴露。还需要评估烟雾通过绕过血脑屏障的嗅觉神经进入中枢神经系统的重要性。
