Saquib Nazmus, Rock Cheryl L, Natarajan Loki, Flatt Shirley W, Newman Vicky A, Thomson Cynthia A, Caan Bette J, Pierce John P
Cancer Prevention and Control Program, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0901, USA.
Health Educ Behav. 2009 Jun;36(3):518-31. doi: 10.1177/1090198108314617. Epub 2009 Jan 30.
A randomized dietary intervention trial across 4 years examined diet, weight, and obesity incidence (body mass index [BMI] > or = 30 kg/m(2)) differences between study groups. Participants were 1,510 breast cancer survivors with BMI > or = 25 kg/m(2) at entry. Dietary intake was assessed yearly by telephone; weight and height were measured at clinic visits. Intervention participants consumed more fruit, vegetables, and fiber and less energy from fat than control participants during follow-up cross-sectionally (p < .0001) and longitudinally (p < .0001); weight did not differ between study groups at any follow-up visit, and significant weight change difference was observed between groups only in the 1st year (p < .0001). Diet and weight results remained unchanged after stratifying by age and BMI. No difference in obesity incidence was found during follow-up (p > .10) among overweight members of either study group. Without specific efforts to reduce total energy intake, dietary modification does not reduce obesity or result in long-term weight loss.
一项为期4年的随机饮食干预试验研究了各研究组之间的饮食、体重和肥胖发生率(体重指数[BMI]≥30kg/m²)差异。参与者为1510名入组时BMI≥25kg/m²的乳腺癌幸存者。每年通过电话评估饮食摄入量;在门诊就诊时测量体重和身高。在随访期间,干预组参与者横断面(p<0.0001)和纵向(p<0.0001)摄入的水果、蔬菜和纤维更多,来自脂肪的能量更少;在任何随访就诊时,研究组之间的体重均无差异,仅在第1年观察到组间显著的体重变化差异(p<0.0001)。按年龄和BMI分层后,饮食和体重结果保持不变。在随访期间,两个研究组中超重成员的肥胖发生率均未发现差异(p>0.10)。在没有具体努力减少总能量摄入的情况下,饮食调整不会降低肥胖率或导致长期体重减轻。