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[7天浸泡对肾脏排泄功能影响的评估]

[Evaluation of the 7-day immersion effect on the renal excretory function].

作者信息

Nesterovskaia A Iu, Morukov B V, Vorontsov A L, Markin A A, Zhuravleva O A, Zabolotskaia I V, Vostrikova L V

出版信息

Aviakosm Ekolog Med. 2008 Sep-Oct;42(5):52-6.

Abstract

In an experiment with 7-d immersion of 8 male test-subjects (21-26 y.o.) we investigated excretion with urine of total protein, creatinine, urea, uric acid, glucose, K, Na, Ca, P, Mg, 12 groups of proteins and 5 enzymes. Results of the investigation bring to the conclusion that 7-d immersion does not impact the kidney functioning. Analysis of uroproteinogram failed to detect shifts in glomerular filtration or tubular reabsorption which correlates with the absence of significant changes in uroenzymogram. Even profuse diuresis was unable to provoke abnormally high protein and glucose excretion, whereas electrolyte excretion normalized fairly soon. Increased excretion of creatinine, urea, Ca, Mg and P appears to reflect activation of catabolism in skeletal muscles.

摘要

在一项对8名男性受试对象(21 - 26岁)进行7天浸泡的实验中,我们研究了尿液中总蛋白、肌酐、尿素、尿酸、葡萄糖、钾、钠、钙、磷、镁、12组蛋白质和5种酶的排泄情况。研究结果得出结论:7天浸泡不会影响肾脏功能。尿蛋白图谱分析未能检测到肾小球滤过或肾小管重吸收的变化,这与尿酶图谱无显著变化相关。即使大量利尿也无法引发异常高的蛋白质和葡萄糖排泄,而电解质排泄很快恢复正常。肌酐、尿素、钙、镁和磷排泄增加似乎反映了骨骼肌分解代谢的激活。

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