Fuligni Andrew J, Telzer Eva H, Bower Julienne, Cole Steve W, Kiang Lisa, Irwin Michael R
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Box 62, Los Angeles, CA 90024, USA.
Psychosom Med. 2009 Apr;71(3):329-33. doi: 10.1097/PSY.0b013e3181921b1f. Epub 2009 Feb 5.
To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years.
A total of 69 adolescents (Mage= 17.78 years) completed daily diary checklists each night for 14 days in which they reported their experience of negative interpersonal interactions in the domains of family, peers, and school (e.g., conflict with family and friends, peer harassment, punishment by parents and teachers). Blood samples were obtained an average of 8.63 months later and assayed for circulating levels of CRP, using enzyme-linked immunosorbent assay. Measures of body mass index (BMI), socioeconomic status (SES), substance use, stressful life events, rejection sensitivity, and psychological distress were obtained.
A greater frequency of daily interpersonal stress was associated with higher levels of CRP, even after controlling for BMI, SES, substance use, life events, rejection sensitivity, psychological distress, and frequency of daily interpersonal stress 2 years earlier.
Experiencing a high frequency of interpersonal stressors that are typical of adolescent life is associated with higher levels of inflammation even among a normative, healthy sample of adolescents. Additional work should focus on other daily experiences during the adolescent period and their implications for elevated risk for later cardiovascular disease.
研究青少年时期日常人际压力经历与C反应蛋白（CRP）水平之间的关联，CRP是一种炎症标志物，也是心血管风险的关键指标。
共有69名青少年（平均年龄=17.78岁）连续14天每晚填写日常日记清单，报告他们在家庭、同伴和学校等方面的负面人际互动经历（例如，与家人和朋友的冲突、同伴骚扰、父母和老师的惩罚）。平均8.63个月后采集血样，采用酶联免疫吸附测定法检测循环中的CRP水平。同时获取体重指数（BMI）、社会经济地位（SES）、物质使用情况、应激性生活事件、拒绝敏感性和心理困扰等指标。
即使在控制了BMI、SES、物质使用、生活事件、拒绝敏感性、心理困扰以及两年前的日常人际压力频率之后，日常人际压力频率越高，CRP水平也越高。
即使在正常、健康的青少年样本中，经历典型的青少年生活中的高频人际压力源也与更高水平的炎症相关。后续研究应关注青少年时期的其他日常经历及其对后期心血管疾病风险升高的影响。
