Binegar Dani L, Hynan Linda S, Lacritz Laura H, Weiner Myron F, Cullum C Munro
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9129, USA.
Curr Alzheimer Res. 2009 Feb;6(1):48-51. doi: 10.2174/156720509787313880.
To determine if a direct measure of instrumental activities of daily living (IADL) scale designed for use with dementia patients can detect differences between persons with mild cognitive impairment (MCI) and normal elderly control subjects (NC).
This study used cross-sectional and longitudinal IADL scale data from MCI and NC subjects followed at an Alzheimer's Disease Center.
On a 52-point scale, MCI subjects (n = 30) scored significantly lower than NC subjects (n = 30) on the IADL scale (total score 47.17 vs. 48.77 points; t (58) = 2.34, p = .011) and its Memory subscale (5.27 vs. 6.6 points; t (58) = 3.29, p = .002).Examination of annualized IADL scale change scores revealed that 50% of MCI subjects had declined by one point, compared with 29% of NC.
A direct IADL measure for dementia patients is able to detect small differences between MCI and NC and cross-sectionally and longitudinally, but does not distinguish between groups.
确定一种专为痴呆患者设计的日常生活工具性活动（IADL）量表能否检测出轻度认知障碍（MCI）患者与正常老年对照受试者（NC）之间的差异。
本研究使用了来自阿尔茨海默病中心随访的MCI和NC受试者的横断面和纵向IADL量表数据。
在一个52分的量表上，MCI受试者（n = 30）在IADL量表上的得分显著低于NC受试者（n = 30）（总分47.17分对48.77分；t（58）= 2.34，p = 0.011）及其记忆子量表（5.27分对6.6分；t（58）= 3.29，p = 0.002）。对IADL量表年度变化得分的检查显示，50%的MCI受试者下降了1分，而NC受试者为29%。
一种针对痴呆患者的直接IADL测量方法能够在横断面和纵向上检测出MCI和NC之间的细微差异，但无法区分不同组。
