用于预防宫颈癌的重组麻疹病毒-人乳头瘤病毒候选疫苗。
Recombinant measles virus-HPV vaccine candidates for prevention of cervical carcinoma.
作者信息
Cantarella Giuseppina, Liniger Matthias, Zuniga Armando, Schiller John T, Billeter Martin, Naim Hussein Y, Glueck Reinhard
机构信息
Etna Biotech srl, Catania, Italy.
出版信息
Vaccine. 2009 May 26;27(25-26):3385-90. doi: 10.1016/j.vaccine.2009.01.061. Epub 2009 Feb 5.
Abstract
Cervical cancer is mainly associated with HPV genotype 16 infection. Recombinant measles virus (rMV) expressing HPV genotype 16 L1 capsid protein was generated by construction of an antigenomic plasmid, followed by rescue using the human "helper" cell line 293-3-46. In cell cultures the recombinant MV-L1 virus replicated practically as efficiently as the standard attenuated MV established as commercial vaccine, devoid of the transgene. The high genetic stability of MVb2-L1 was confirmed by 10 serial viral transfers in cell culture. In transgenic mice expressing the MV receptor CD46 the recombinant induced strong humoral immune responses against both MV and HPV; the antibodies against L1 exhibited mainly neutralizing capacity. Our data suggest that MV is a promising vehicle for development of inexpensive and efficient vaccines protecting from HPV infection.
摘要
宫颈癌主要与16型人乳头瘤病毒（HPV）感染有关。通过构建反基因组质粒，随后使用人“辅助”细胞系293 - 3 - 46进行拯救，产生了表达16型HPV L1衣壳蛋白的重组麻疹病毒（rMV）。在细胞培养中，重组MV - L1病毒的复制效率实际上与作为商业疫苗的标准减毒麻疹病毒一样高，且不含转基因。通过在细胞培养中进行10次连续病毒传代，证实了MVb2 - L1具有高度的遗传稳定性。在表达麻疹病毒受体CD46的转基因小鼠中，该重组体诱导了针对麻疹病毒和HPV的强烈体液免疫反应；针对L1的抗体主要表现出中和能力。我们的数据表明，麻疹病毒是开发预防HPV感染的廉价高效疫苗的有前景的载体。
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