酪氨酸拉定A和B，来自一种海绵纲海绵的带有咪唑基喹啉酮部分的新型溴酪氨酸生物碱。

Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a verongid sponge.

作者信息

Mukai Hiroya, Kubota Takaaki, Aoyama Kazuki, Mikami Yuzuru, Fromont Jane, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1337-9. doi: 10.1016/j.bmcl.2009.01.056. Epub 2009 Jan 23.

DOI:10.1016/j.bmcl.2009.01.056

PMID:19201605

Abstract

Two new bromotyrosine alkaloids, tyrokeradines A (1) and B (2), with an imidazolyl-quinolinone moiety have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data.

摘要

从冲绳岛一种属于Verongida目的海洋海绵中分离出了两种新的含咪唑基喹啉酮部分的溴酪氨酸生物碱——酪氨酸角鲨胺A（1）和B（2）。根据光谱数据阐明了1和2的结构。