Ruan Xiangyan, Dai Yujie
Department of Endocrinology for Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Med Princ Pract. 2009;18(2):118-22. doi: 10.1159/000189809. Epub 2009 Feb 9.
To determine whether or not there is an increased level of serum C-reactive protein (CRP), of peripheral white cell count and of associated factors in Chinese patients with polycystic ovary syndrome (PCOS).
Seventy-four patients with PCOS were recruited for the study. The control group consisted of 51 normal healthy women of a similar age and body mass index (BMI). The basic physical parameters, white cell count, CRP, sex hormone and fasting insulin were measured. The glycolipid metabolic index and the insulin sensitivity index were calculated.
The serum CRP level (2.13 vs. 0.86 mg/l, p < 0.001) and total leukocyte count (7.50 +/- 1.83 vs. 6.55 +/- 1.66 x 10(9)/l, p < 0.01) were significantly higher in PCOS patients than in normal healthy women. Even PCOS patients with normal BMI had an increase in CRP and leukocyte count. The serum CRP level of PCOS patients was positively correlated with BMI (R = 0.57, p < 0.001) and triglycerides (R = 0.47, p < 0.001) and negatively correlated with the insulin sensitivity index (R = -0.60, p < 0.001).
The data showed that chronic nonspecific inflammation exists among Chinese patients with PCOS and that this kind of inflammation was related to insulin resistance, BMI, and triglycerides.
确定中国多囊卵巢综合征（PCOS）患者的血清C反应蛋白（CRP）水平、外周白细胞计数及相关因素是否升高。
招募74例PCOS患者进行研究。对照组由51名年龄和体重指数（BMI）相近的正常健康女性组成。测量基本身体参数、白细胞计数、CRP、性激素和空腹胰岛素。计算糖脂代谢指数和胰岛素敏感性指数。
PCOS患者的血清CRP水平（2.13 vs. 0.86 mg/l，p < 0.001）和白细胞总数（7.50 +/- 1.83 vs. 6.55 +/- 1.66 x 10(9)/l，p < 0.01）显著高于正常健康女性。即使BMI正常的PCOS患者，其CRP和白细胞计数也有所升高。PCOS患者的血清CRP水平与BMI（R = 0.57，p < 0.001）和甘油三酯（R = 0.47，p < 0.001）呈正相关，与胰岛素敏感性指数（R = -0.60，p < 0.001）呈负相关。
数据表明，中国PCOS患者存在慢性非特异性炎症，且这种炎症与胰岛素抵抗、BMI和甘油三酯有关。
