Department of Dermatology, Adelaide and Meath Hospital incorporating National Children's Hospital, Tallaght, Dublin, Ireland.
Clin Exp Dermatol. 2011 Jan;36(1):19-23. doi: 10.1111/j.1365-2230.2010.03877.x.
Psoriasis is a hyperproliferative, cutaneous disorder with the potential to lower levels of folate. This may result in raised levels of homocysteine, an independent risk factor for the development of cardiovascular disease.
A study was conducted to compare levels of red-cell folate (RCF) and homocysteine in patients with psoriasis and in healthy controls. Levels of homocysteine were also examined in the context of other major cardiovascular risk factors.
In total, 20 patients with psoriasis and 20 controls had their RCF, homo-cysteine and other conventional cardiovascular risk factors assessed.
Patients with psoriasis had a trend towards lower levels of RCF. Significantly raised levels of homocysteine were found in patients with psoriasis compared with controls (P = 0.007). There was no correlation between homocysteine levels, RCF levels or disease activity as measured by the Psoriasis Area and Severity Index. Patients with psoriasis had higher body mass index (P < 0.004) and higher systolic blood pressure (P < 0.001) than controls. This may contribute to the excess cardiovascular mortality observed in patients with psoriasis.
银屑病是一种皮肤过度增生性疾病，可能导致叶酸水平降低。这可能导致同型半胱氨酸水平升高，同型半胱氨酸是心血管疾病发展的独立危险因素。
本研究旨在比较银屑病患者和健康对照者的红细胞叶酸（RCF）和同型半胱氨酸水平。还检查了同型半胱氨酸水平与其他主要心血管危险因素的关系。
共评估了 20 例银屑病患者和 20 例对照者的 RCF、同型半胱氨酸和其他常规心血管危险因素。
银屑病患者的 RCF 水平呈下降趋势。与对照组相比，银屑病患者的同型半胱氨酸水平显著升高（P = 0.007）。同型半胱氨酸水平与 RCF 水平或银屑病面积和严重程度指数（PASI）测量的疾病活动度之间无相关性。银屑病患者的体重指数（BMI）（P < 0.004）和收缩压（SBP）（P < 0.001）均高于对照组。这可能导致银屑病患者观察到的心血管死亡率过高。
