Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Altern Complement Med. 2009 Feb;15(2):129-32. doi: 10.1089/acm.2008.0311.
To compare the effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.
This was a double-blind comparative clinical trial conducted from September 2006 to February 2007. Participants were 150 students (18 years old and over) with primary dysmenorrhea from the dormitories of two medical universities who were alternately divided into three equal groups. Students in the ginger group took 250 mg capsules of ginger rhizome powder four times a day for three days from the start of their menstrual period. Members of the other groups received 250 mg mefenamic acid or 400 mg ibuprofen capsules, respectively, on the same protocol. A verbal multidimensional scoring system was used for assessing the severity of primary dysmenorrhea. Severity of disease, pain relief, and satisfaction with the treatment were compared between the groups after one menstruation.
There were not significant differences between groups in baseline characteristics, p > 0.05. At the end of treatment, severity of dysmenorrhea decreased in all groups and no differences were found between the groups in severity of dysmenorrhea, pain relief, or satisfaction with the treatment, p > 0.05. No severe side effects occurred.
Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea. Further studies regarding the effects of ginger on other symptoms associated with dysmenorrhea and efficacy and safety of various doses and treatment durations of ginger are warranted.
比较生姜、甲芬那酸和布洛芬对原发性痛经妇女疼痛的影响。
这是一项于 2006 年 9 月至 2007 年 2 月进行的双盲对照临床试验。参与者为来自两所医学院宿舍的 150 名（18 岁及以上）原发性痛经女学生，她们被交替分为三组，每组人数相等。生姜组学生从月经开始时每天服用 4 次 250 毫克的生姜根茎粉胶囊，连续服用 3 天。其他两组学生分别按照相同的方案服用 250 毫克甲芬那酸或 400 毫克布洛芬胶囊。采用口头多维评分系统评估原发性痛经的严重程度。在一次月经后，比较各组之间疾病严重程度、疼痛缓解程度和对治疗的满意度。
各组在基线特征方面无显著差异，p>0.05。治疗结束时，所有组的痛经严重程度均有所下降，各组之间痛经严重程度、疼痛缓解程度或对治疗的满意度无差异，p>0.05。未发生严重不良反应。
生姜在缓解原发性痛经妇女疼痛方面与甲芬那酸和布洛芬同样有效。需要进一步研究生姜对痛经相关其他症状的影响，以及生姜不同剂量和治疗持续时间的疗效和安全性。
