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用于高分辨率核磁共振波谱学和成像的移动传感器。

Mobile sensor for high resolution NMR spectroscopy and imaging.

作者信息

Danieli Ernesto, Mauler Jörg, Perlo Juan, Blümich Bernhard, Casanova Federico

机构信息

Institut für Technische Chemie und Makromolekulare Chemie, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.

出版信息

J Magn Reson. 2009 May;198(1):80-7. doi: 10.1016/j.jmr.2009.01.022. Epub 2009 Jan 25.

Abstract

In this work we describe the construction of a mobile NMR tomograph with a highly homogeneous magnetic field. Fast MRI techniques as well as NMR spectroscopy measurements were carried out. The magnet is based on a Halbach array built from identical permanent magnet blocks generating a magnetic field of 0.22T. To shim the field inhomogeneities inherent to magnet arrays constructed from these materials, a shim strategy based on the use of movable magnet blocks is employed. With this approach a reduction of the line-width from approximately 20kHz to less than 0.1kHz was achieved, that is by more than two orders of magnitude, in a volume of 21cm(3). Implementing a RARE sequence, 3D images of different objects placed in this volume were obtained in short experimental times. Moreover, by reducing the sample size to 1cm(3), sub ppm resolution is obtained in (1)H NMR spectra.

摘要

在这项工作中,我们描述了一种具有高度均匀磁场的移动核磁共振断层扫描仪的构建。进行了快速磁共振成像技术以及核磁共振波谱测量。该磁体基于由相同永磁体块构建的哈尔巴赫阵列,可产生0.22T的磁场。为了补偿由这些材料构建的磁体阵列固有的场不均匀性,采用了一种基于使用可移动磁体块的匀场策略。通过这种方法,在21cm³的体积内,线宽从大约20kHz降低到小于0.1kHz,即降低了两个多数量级。通过实施RARE序列,在短实验时间内获得了放置在该体积内不同物体的三维图像。此外,通过将样品尺寸减小到1cm³,在¹H核磁共振谱中获得了亚ppm分辨率。

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