Zilman Anton
Theoretical Biology and Biophysics Group and Center for Nonlinear Studies, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Biophys J. 2009 Feb 18;96(4):1235-48. doi: 10.1016/j.bpj.2008.09.058.
Many biological and artificial transport channels function without direct input of metabolic energy during a transport event and without structural rearrangements involving transitions from a closed to an open state. Nevertheless, such channels are able to maintain efficient and selective transport. It has been proposed that attractive interactions between the transported molecules and the channel can increase the transport efficiency and that the selectivity of such channels can be based on the strength of the interaction of the specifically transported molecules with the channel. Herein, we study the transport through narrow channels in a framework of a general kinetic theory, which naturally incorporates multiparticle occupancy of the channel and non-single-file transport. We study how the transport efficiency and the probability of translocation through the channel are affected by interparticle interactions in the confined space inside the channel, and establish conditions for selective transport. We compare the predictions of the model with the available experimental data and find good semiquantitative agreement. Finally, we discuss applications of the theory to the design of artificial nanomolecular sieves.
许多生物和人工运输通道在运输过程中无需直接输入代谢能量，也无需涉及从关闭状态到开放状态转变的结构重排即可发挥作用。然而，此类通道能够维持高效且选择性的运输。有人提出，被运输分子与通道之间的吸引相互作用可提高运输效率，并且此类通道的选择性可基于特定运输分子与通道相互作用的强度。在此，我们在一个通用动力学理论框架内研究通过狭窄通道的运输，该理论自然地纳入了通道的多粒子占据和非单文件运输。我们研究通道内部受限空间中的粒子间相互作用如何影响运输效率和通过通道转运的概率，并建立选择性运输的条件。我们将模型的预测结果与现有的实验数据进行比较，发现有良好的半定量一致性。最后，我们讨论该理论在人工纳米分子筛设计中的应用。
