Zilman A, Pearson J, Bel G
Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
Phys Rev Lett. 2009 Sep 18;103(12):128103. doi: 10.1103/PhysRevLett.103.128103. Epub 2009 Sep 17.
Many biological channels perform highly selective transport without direct input of metabolic energy and without transitions from a "closed" to an "open" state during transport. Mechanisms of selectivity of such channels serve as an inspiration for creation of artificial nanomolecular sorting devices and biosensors. To elucidate the transport mechanisms, it is important to understand the transport on the single molecule level in the experimentally relevant regime when multiple particles are crowded in the channel. In this Letter we analyze the effects of interparticle crowding on the nonequilibrium transport times through a finite-length channel by means of analytical theory and computer simulations.
许多生物通道在不直接输入代谢能量且在运输过程中不发生从“关闭”到“开放”状态转变的情况下，就能实现高度选择性的运输。此类通道的选择性机制为人工纳米分子分选装置和生物传感器的创建提供了灵感。为了阐明运输机制，重要的是要了解在实验相关条件下，当多个粒子在通道中拥挤时单分子水平上的运输情况。在本信函中，我们通过解析理论和计算机模拟分析了粒子间拥挤对通过有限长度通道的非平衡运输时间的影响。
