Tadbir Azadeh Andisheh, Ashraf Mohammad Javad, Sardari Yasaman
Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. andisheh202003@yahoo
J Craniofac Surg. 2009 Mar;20(2):287-9. doi: 10.1097/SCS.0b013e318199219b.
Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.
肿瘤相关组织嗜酸性粒细胞增多症（TATE）已在包括头颈部在内的许多部位被描述。本研究的目的是调查TATE作为口腔鳞状细胞癌（OSCC）预后因素的患病率及其可能作用。对76例连续诊断为OSCC的患者进行了评估，并在肿瘤的3个不同区域获取嗜酸性粒细胞数量。从肿瘤分化、神经周围、血管和肌肉浸润（组织病理学参数）以及局部区域转移（临床参数）方面研究了TATE作为OSCC预后因素的可能作用。在3个不同区域的大多数病例中，肿瘤相关组织嗜酸性粒细胞增多症程度较低。肿瘤浸润前沿的嗜酸性粒细胞平均计数高于肿瘤内基质和表面上皮下方的基质。TATE与肿瘤分化、神经周围、血管和肌肉浸润以及局部区域转移之间的关系无统计学意义（P>0.05）。肿瘤相关组织嗜酸性粒细胞增多症与OSCC的预后参数无关。
