细胞色素c胰蛋白酶片段之间的功能性复合物。半合成类似物的生产途径。
A functioning complex between tryptic fragments of cytochrome c. A route to the production of semisynthetic analogues.
作者信息
Harris D E, Offord R E
出版信息
Biochem J. 1977 Jan 1;161(1):21-5. doi: 10.1042/bj1610021.
Abstract
We report the discovery of a functioning non-covalent complex between two peptides obtained from a limited tryptic digest of horse heart cytochrome c. We have used the phenomenon to produce three modified versions of the complex. We have replaced lysine-39 semisynthetically with ornithine in the first analogue, with p-fluorophenyl-alanine in the second, and removed it entirely in the third.
摘要
我们报告了从马心细胞色素c的有限胰蛋白酶消化产物中获得的两种肽之间形成功能性非共价复合物的发现。我们利用这一现象制备了该复合物的三个修饰版本。在第一个类似物中，我们用鸟氨酸半合成取代了赖氨酸-39；在第二个类似物中，用对氟苯丙氨酸取代；在第三个类似物中，将其完全去除。
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