Inoue Atsuo, Tomiyama Noriyuki, Tatsumi Mitsuaki, Ikeda Naoki, Okumura Meinoshin, Shiono Hiroyuki, Inoue Masayoshi, Higuchi Ichiro, Aozasa Katsuyuki, Johkoh Takeshi, Nakamura Hironobu, Hatazawa Jun
Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Eur J Nucl Med Mol Imaging. 2009 Aug;36(8):1219-25. doi: 10.1007/s00259-009-1082-4. Epub 2009 Feb 14.
Our aim was to determine dual-phase (18)F-FDG PET imaging features for various subtypes of thymic epithelial tumors based on the World Health Organization classification.
Forty-six patients with histologically verified thymic epithelial tumors [23 with low-risk tumors (4 with type A, 16 with AB, and 3 with B1) and 23 with high-risk tumors (7 with B2, 5 with B3, and 11 with thymic carcinoma] were enrolled in this study. All patients were injected with (18)F-FDG.; after 1 h, they underwent scanning; after 3 h, 23 patients underwent an additional scanning. The maximum standard uptake value (SUV(max)) and the retention index (RI%) of the lesions were determined.
The early and delayed SUV(max) values in the patients with high-risk tumors [early SUV(max) (mean: 6.0) and delayed SUV(max) (mean: 7.4)] were both significantly larger than those in patients with low-risk tumors [early SUV(max) (mean: 3.2) and delayed SUV(max) (mean: 3.4)] (P < 0.05). Early SUV(max) values of greater than 7.1 differentiated thymic carcinomas from other types of tumors. For the histological differentiation between high-risk tumors and low-risk tumors, an early SUV(max) value of 4.5 was used as the cutoff. The sensitivity, specificity, and accuracy were 78.3, 91.3, and 84.8%, respectively.
High SUV values (early SUV > 4.5) suggest the presence of high-risk tumors. A very high SUV value (early SUV > 7.1) is useful for the differentiation of thymic carcinomas from other types of tumors. The delayed SUV values were higher than the early SUV values in all types of tumors.
我们的目的是基于世界卫生组织分类法，确定不同亚型胸腺上皮肿瘤的双期（18）F-FDG PET成像特征。
46例经组织学证实的胸腺上皮肿瘤患者[23例低风险肿瘤患者（4例A型、16例AB型和3例B1型）和23例高风险肿瘤患者（7例B2型、5例B3型和11例胸腺癌）]纳入本研究。所有患者均注射（18）F-FDG；1小时后进行扫描；3小时后，23例患者进行额外扫描。测定病变的最大标准摄取值（SUV（max））和滞留指数（RI%）。
高风险肿瘤患者的早期和延迟SUV（max）值[早期SUV（max）（均值：6.0）和延迟SUV（max）（均值：7.4）]均显著高于低风险肿瘤患者[早期SUV（max）（均值：3.2）和延迟SUV（max）（均值：3.4）]（P<0.05）。早期SUV（max）值大于7.1可将胸腺癌与其他类型肿瘤区分开来。对于高风险肿瘤与低风险肿瘤的组织学鉴别，以早期SUV（max）值4.5作为临界值。敏感性、特异性和准确性分别为78.3%、91.3%和84.8%。
高SUV值（早期SUV>4.5）提示存在高风险肿瘤。非常高的SUV值（早期SUV>7.1）有助于将胸腺癌与其他类型肿瘤区分开来。所有类型肿瘤的延迟SUV值均高于早期SUV值。
