Wang Giueng-Chueng, Hsieh Po-Shiuan, Hsu Hsian-He, Sun Guang-Huan, Nieh Shin, Yu Cheng-Ping, Jin Jong-Shiaw
Department of Clinical Pathology, Tri-Service General Hospital and Taipei Medical University-Municipal Wan Fang Hospital, Taipei, Taiwan, ROC.
World J Urol. 2009 Aug;27(4):557-63. doi: 10.1007/s00345-009-0376-2. Epub 2009 Feb 15.
We tested the hypothesis that the expression of cortactin and survivin in renal cell carcinomas (RCCs) correlates with more advanced stages of the disease.
Immunohistochemical analysis of cortactin and survivin expression (scored on a scale of 0-400) was performed in 124 renal cell carcinomas including clear cell renal cell carcinoma (CRCC), papillary RCC (PRCC), CRCC with sarcomatoid differentiation (SRCC), chromophobe RCC (ChRCC), and CRCC with granular cell differentiation (GRCC).
Higher cortactin scores in CRCC were significantly correlated with higher T (p = 0.021) and N stages (p = 0.036), and nuclear grade (p = 0.012). Higher cortactin immunostaining scores were associated with higher mortality (p = 0.035). In addition, the survivin scores were significantly higher in the more aggressive GRCC and SRCC than in CRCC, suggesting a significant role of survivin expression in transformation of tumor cells to a more malignant phenotype.
Higher expression of cortactin and survivin significantly correlated with advanced clinicopathological stage. Our findings support the potential targeting of survivin and cortactin for the development of novel therapeutic strategies for renal cell carcinoma.
我们检验了如下假设，即肾细胞癌（RCC）中皮质肌动蛋白（cortactin）和生存素（survivin）的表达与疾病的更晚期阶段相关。
对124例肾细胞癌进行了皮质肌动蛋白和生存素表达的免疫组织化学分析（评分范围为0 - 400），这些肾细胞癌包括透明细胞肾细胞癌（CRCC）、乳头状肾细胞癌（PRCC）、具有肉瘤样分化的CRCC（SRCC）、嫌色细胞肾细胞癌（ChRCC）以及具有颗粒细胞分化的CRCC（GRCC）。
CRCC中较高的皮质肌动蛋白评分与较高的T分期（p = 0.021）、N分期（p = 0.036）以及核分级（p = 0.012）显著相关。较高的皮质肌动蛋白免疫染色评分与较高的死亡率相关（p = 0.035）。此外，侵袭性更强的GRCC和SRCC中的生存素评分显著高于CRCC，提示生存素表达在肿瘤细胞向更恶性表型转化中起重要作用。
皮质肌动蛋白和生存素的高表达与晚期临床病理分期显著相关。我们的研究结果支持将生存素和皮质肌动蛋白作为肾细胞癌新型治疗策略开发的潜在靶点。
