zur Hausen H
Arzneimittelforschung. 1977 Jan;27(1B):212-5.
Various types of human papillomas (warts) can be differentiated according to clinical parameters: Verrucae vulgares, plantares, planae and seborrheicae, in addition genital warts (Condylomata acuminata) and laryngeal papillomas. With the exception of Verrucae vulgares and plantares the epidemiology of these types of warts displays significantly different patterns. It was possible to demonstrate the heterogeneity of human wart viruses also by biochemical and serological means: we have identified 4 different types of human papilloma viruses so far, 3 of which are closely related with each other. Their potential role in the induction of malignant tumors in man is discussed.
根据临床参数可区分出各种类型的人类乳头瘤(疣):寻常疣、跖疣、扁平疣、脂溢性疣,此外还有尖锐湿疣和喉乳头瘤。除寻常疣和跖疣外,这些类型的疣的流行病学表现出显著不同的模式。通过生化和血清学方法也能够证明人类疣病毒的异质性:到目前为止,我们已经鉴定出4种不同类型的人类乳头瘤病毒,其中3种彼此密切相关。文中讨论了它们在人类恶性肿瘤诱发中可能发挥的作用。