清相散对脾胃湿热证大鼠模型P物质、生长抑素的影响
[Influence of Qingxiang San on substance P, somatostatin in rats model with the spleen and stomach wet heat syndrome].
作者信息
Tan Yong-Zhen, Wen Xiao-Min, Chen Pei-Chan, Li Yu-Jing, Chen Pei-Hong, Huang Gui-Qiong
机构信息
College of TCM, Southern Medical University, Guangzhou 510515, China.
出版信息
Zhong Yao Cai. 2008 Oct;31(10):1526-8.
OBJECTIVE
To observe the influence of Qingxiang San (QS) on substance P (SP), somatostatin (SS) in rats model of spleen and stomach wet heat syndrome.
METHODS
24 rats were divided into 3 groups (each group 8 rats) randomly: the normal control group (NCG), wet heat group (WHG), QS group (QSG). We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment, pathogen and so on. Then the contents of SP, SS were detected by radioimmuno assay.
RESULTS
The content of SP, SS in WHG were obviously lower than NCG (P<0.01); QSG compared with WHG, the content of SP, SS increased (P<0.01); The content of SP obviously increased when QSG compared with NCG (P<0.01); About the content of SS, there was no significant difference between QSG and NCG (P>0.05), illustrating that QS can increase the content of SP, SS which had decreased.
CONCLUSION
QS can regulate the content of SP and SS and increase them which had decreased.
目的
观察清相散（QS）对脾胃湿热证大鼠模型中P物质（SP）、生长抑素（SS）的影响。
方法
将24只大鼠随机分为3组（每组8只）：正常对照组（NCG）、湿热组（WHG）、清相散组（QSG）。通过高脂高糖饮食、湿热环境、病原体等复合因素建立大鼠脾胃湿热证模型。然后采用放射免疫分析法检测SP、SS的含量。
结果
WHG组SP、SS含量明显低于NCG组（P<0.01）；QSG组与WHG组比较，SP、SS含量升高（P<0.01）；QSG组与NCG组比较，SP含量明显升高（P<0.01）；关于SS含量，QSG组与NCG组之间无显著差异（P>0.05），说明清相散可升高降低的SP、SS含量。
结论
清相散可调节SP和SS的含量并升高降低的含量。
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