Int J Cardiol. 2010 Dec 3;145(3):e99-101. doi: 10.1016/j.ijcard.2008.12.166. Epub 2009 Feb 23.
Measurement of functional tissue perfusion should be needed for preventive measures, early diagnosis, and adequate treatment especially in the patients with peripheral vascular diseases (PVD). Significant attention has also been given to in vivo near-infrared (NIR) fluorescence imaging because of deep tissue penetration due to low absorbance and scattering. In this study, a new method, indocyanine green (ICG) perfusion imaging to evaluate the peripheral tissue perfusion that employs the intravenous injection of ICG dye, planar imaging with a CCD digital imaging system, and analysis of spatiotemporal dynamics have been applied to diagnose perfusion rate of human lower extremities from a normal and a PVD case. The feet tissue perfusions of the PVD patient were measured as 25% to 50% compared with those of normal feet tissue. The diagnostic result indicates that ICG perfusion imaging method is sensitive enough to diagnose PVD and take noninvasive monitoring treatment effects of peripheral vascular diseases in clinical setting.
功能组织灌注的测量对于预防措施、早期诊断和充分治疗，尤其是对于外周血管疾病（PVD）患者来说非常重要。由于近红外（NIR）光的低吸收率和低散射率，其具有深层组织穿透能力，因此其在体内的应用也得到了极大的关注。在这项研究中，我们应用了一种新的方法，即使用静脉注射吲哚菁绿（ICG）染料、采用 CCD 数字成像系统进行平面成像以及分析时空动力学的方法来评估外周组织灌注，从而对正常和 PVD 病例的人体下肢灌注率进行评估。与正常足部组织相比，PVD 患者足部组织的灌注量为 25%至 50%。诊断结果表明，ICG 灌注成像方法足以灵敏地诊断 PVD，并能在临床环境中进行对外周血管疾病的无创监测和治疗效果评估。
