细菌中的调控RNA
Regulatory RNAs in bacteria.
作者信息
Waters Lauren S, Storz Gisela
机构信息
Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
出版信息
Cell. 2009 Feb 20;136(4):615-28. doi: 10.1016/j.cell.2009.01.043.
Abstract
Bacteria possess numerous and diverse means of gene regulation using RNA molecules, including mRNA leaders that affect expression in cis, small RNAs that bind to proteins or base pair with target RNAs, and CRISPR RNAs that inhibit the uptake of foreign DNA. Although examples of RNA regulators have been known for decades in bacteria, we are only now coming to a full appreciation of their importance and prevalence. Here, we review the known mechanisms and roles of regulatory RNAs, highlight emerging themes, and discuss remaining questions.
摘要
细菌拥有多种利用RNA分子进行基因调控的方式，包括影响顺式表达的mRNA前导序列、与蛋白质结合或与靶RNA碱基配对的小RNA，以及抑制外源DNA摄取的CRISPR RNA。尽管细菌中RNA调控因子的例子已为人所知数十年，但我们直到现在才充分认识到它们的重要性和普遍性。在这里，我们综述了调控RNA的已知机制和作用，突出了新出现的主题，并讨论了尚存的问题。
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