Tanel Andre, Fonseca Simone G, Yassine-Diab Bader, Bordi Rebeka, Zeidan Joumana, Shi Yu, Benne Clarisse, Sékaly Rafick-Pierre
Laboratoire d'Immunologie, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) Saint-Luc, 264 Rene Levesque Est, Montréal, Québec H2X 1P1, Canada.
Expert Rev Vaccines. 2009 Mar;8(3):299-312. doi: 10.1586/14760584.8.3.299.
Long-term maintenance of the memory T-cell response is the hallmark of immune protection and, hence, constitutes one of the most important objectives of vaccine-development strategies. Persistent memory T cells, developed after vaccination or microbial infections, ensure the generation of an antimicrobial response upon re-exposure to the pathogen through rapid clonal proliferation and activation of effector functions. However, in the context of many pathogen infections, these memory T cells fail to persist and die. In this review, we will highlight recent exciting findings in studies of memory T cells, their generation, their lineage relationships and their survival pathways; indeed, survival of memory T cells and maintenance of their functionality are key features of the immune response in its quest to control disease progression and in the development of vaccines to persistent microbial infections.
记忆性T细胞应答的长期维持是免疫保护的标志，因此也是疫苗研发策略最重要的目标之一。接种疫苗或遭受微生物感染后产生的持久性记忆性T细胞，通过快速克隆增殖和效应功能激活，确保再次接触病原体时产生抗菌应答。然而，在许多病原体感染的情况下，这些记忆性T细胞无法持续存在并死亡。在本综述中，我们将重点介绍记忆性T细胞研究中的最新激动人心的发现，包括它们的产生、谱系关系和存活途径；事实上，记忆性T细胞的存活及其功能的维持是免疫应答在控制疾病进展以及研发针对持续性微生物感染的疫苗方面的关键特征。
