Fields K, Falla T J, Rodan K, Bush L
Helix Biomedix Inc, Bothell, WA, USA.
J Cosmet Dermatol. 2009 Mar;8(1):8-13. doi: 10.1111/j.1473-2165.2009.00416.x.
Natural processes within the body are modulated almost exclusively by the interaction of specific amino acid sequences, either as peptides or as subsections of proteins. With respect to skin, proteins and peptides are involved in the modulation of cell proliferation, cell migration, inflammation, angiogenesis, melanogenesis, and protein synthesis and regulation. The creation of therapeutic or bioactive peptide analogs of specific interactive sequences has opened the door to a diverse new field of pharmaceutical and active cosmetic ingredients for the skincare industry. Here, we describe the origin of such sequences, their role in nature, their application to dermatology, as well as the advantages and challenges posed by this new technology.
体内的自然过程几乎完全由特定氨基酸序列的相互作用来调节，这些氨基酸序列可以是肽，也可以是蛋白质的亚部分。就皮肤而言，蛋白质和肽参与细胞增殖、细胞迁移、炎症、血管生成、黑色素生成以及蛋白质合成与调节的调节过程。特定相互作用序列的治疗性或生物活性肽类似物的产生，为护肤品行业带来了一个多样化的新型药物和活性化妆品成分领域。在此，我们描述这些序列的起源、它们在自然界中的作用、它们在皮肤病学中的应用，以及这项新技术带来的优势和挑战。
