Chen Chuang, Peng Jun, Xia He-Shun, Yang Gui-Fang, Wu Qiong-Shui, Chen Liang-Dong, Zeng Li-Bo, Zhang Zhi-Ling, Pang Dai-Wen, Li Yan
Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, PR China.
Biomaterials. 2009 May;30(15):2912-8. doi: 10.1016/j.biomaterials.2009.02.010. Epub 2009 Feb 28.
HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in this paper. A QDs HER2 probe kit and QDs image acquisition and analysis software were developed and applied to 94 clinical samples of BC. Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis.
人表皮生长因子受体2（HER2）检测对于乳腺癌（BC）的治疗和预后至关重要，但目前使用的检测方法存在一些缺点。基于量子点（QDs）的探针为临床实践中HER2的检测提供了一种潜在的重要新方法。本文对这种潜力进行了研究。开发了一种量子点HER2探针试剂盒以及量子点图像采集与分析软件，并将其应用于94例乳腺癌临床样本。与传统免疫组织化学技术相比，该方法为临床乳腺癌诊断中HER2的检测提供了一种更准确、灵敏的方法。
