用于生物成像的比率型单纳米颗粒氧传感器。
Ratiometric single-nanoparticle oxygen sensors for biological imaging.
作者信息
Wu Changfeng, Bull Barbara, Christensen Kenneth, McNeill Jason
机构信息
Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
出版信息
Angew Chem Int Ed Engl. 2009;48(15):2741-5. doi: 10.1002/anie.200805894.
Abstract
It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.
摘要
这是有道理的
掺杂铂卟啉染料的共轭聚合物纳米颗粒表现出明亮的磷光，对分子氧浓度高度敏感。其小尺寸、非凡的亮度、出色的灵敏度和比率发射，以及单颗粒传感和细胞摄取的证明，表明了纳米颗粒传感器在定量绘制局部分子氧浓度方面的潜力。
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