Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.
Soc Cogn Affect Neurosci. 2012 Jun;7(5):506-15. doi: 10.1093/scan/nsp005. Epub 2009 Mar 3.
Recent research on potential applications of fMRI in the detection of concealed knowledge primarily ascribed the reported differences in hemodynamic response patterns to deception. This interpretation is challenged by the results of the present study. Participants were required to memorize probe and target items (a banknote and a playing card, each). Subsequently, these items were repeatedly presented along with eight irrelevant items in a modified Guilty Knowledge Test design and participants were instructed to simply acknowledge item presentation by pressing one button after each stimulus. Despite the absence of response monitoring demands and thus overt response conflicts, the experiment revealed a differential physiological response pattern as a function of item type. First, probes elicited the largest skin conductance responses. Second, differential hemodynamic responses were observed in bilateral inferior frontal regions, the right supramarginal gyrus and the supplementary motor area as a function of item type. Probes and targets were accompanied by a larger signal increase than irrelevant items in these regions. Moreover, the responses to probes differed substantially from targets. The observed neural response pattern seems to rely on retrieval processes that depend on the depth of processing in the encoding situation.
最近的研究表明，功能磁共振成像（fMRI）在探测隐藏知识方面的潜在应用，主要归因于报告的血流动力学反应模式差异与欺骗有关。本研究的结果对这一解释提出了挑战。参与者需要记住探针和目标项目（一张钞票和一张扑克牌，每张）。随后，这些项目与八个不相关的项目一起以改良的有罪知识测试设计重复呈现，并指示参与者在每个刺激后仅通过按下一个按钮来确认项目呈现。尽管没有响应监控要求，因此没有明显的响应冲突，但实验显示出作为项目类型函数的不同生理反应模式。首先，探针引起最大的皮肤电反应。其次，在双侧额下回、右侧缘上回和辅助运动区观察到与项目类型相关的差异性血流动力学反应。与这些区域的无关项目相比，探针和目标项目伴随着更大的信号增加。此外，探针的反应与目标明显不同。观察到的神经反应模式似乎依赖于检索过程，而这些检索过程依赖于编码情境中的加工深度。
