Prismatoid light guide array for enhanced gamma ray localization in PET: a Monte Carlo simulation study of scintillation photon transport.

High spatial resolution PET relies on having excellent depth-of-interaction (DOI) resolution and small detector elements. Depth-encoding in PET modules has traditionally been performed using dual-ended readout. In recent years, researchers have explored the feasibility of replacing the second readout array with a light guide at the entrance layer that introduces intercrystal light sharing in order to reduce cost and and make depth-encoding modules more compact. However, single-ended readout depth-encoding modules have suboptimal and non-uniform crystal separation and DOI performance due to the random light sharing patterns of the uniform light guide, resulting in degraded peformance along the edges and corners of the detector arrays. In this paper, we introduce and characterize a segmented light guide composed of an array of prism mirrors which introduce deterministic intercrystal light sharing in single-ended readout PET detectors. We determined the expected spatial performance of our modules with our light guide using optical ray tracing Monte Carlo simulations. We demonstrate that having controlled, deterministic light sharing improves both DOI and crystal identification performance, enabling uniform spatial performance throughout the detector array. Designed specifically for high resolution PET, our prismatoid light guide array can be used to build cost-effective total-body and organ-dedicated PET systems with single-ended readout depth-encoding modules.