Durduran Turgut, Zhou Chao, Edlow Brian L, Yu Guoqiang, Choe Regine, Kim Meeri N, Cucchiara Brett L, Putt Mary E, Shah Qaisar, Kasner Scott E, Greenberg Joel H, Yodh Arjun G, Detre John A
Departments of Radiology, University of Pennsylvania, PA, USA.
Opt Express. 2009 Mar 2;17(5):3884-902. doi: 10.1364/oe.17.003884.
"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30 degrees , 15 degrees , 0 degrees , -5 degrees and 0 degrees angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO(2)) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.
“扩散相关光谱法”（DCS）是一种用于无创经颅测量脑血流量（CBF）的技术，它可以与“近红外光谱法”（NIRS）相结合。综合起来，这些方法在监测中风患者的血流动力学方面具有潜力。我们探讨了DCS和NIRS在测量急性缺血性中风累及额叶皮质的患者及对照组中床头（HOB）处于30度、15度、0度、-5度和0度角度时的影响的效用。HOB位置显著改变了CBF、氧合血红蛋白（HbO₂）和总血红蛋白（THC）浓度。此外，同侧梗死的存在对所有参数都有显著影响。结果与梗死半球CBF自动调节受损的观点一致。
