Lawrence Benjamin J, Madihally Sundararajan V
School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Cell Adh Migr. 2008 Jan-Mar;2(1):9-16. doi: 10.4161/cam.2.1.5884. Epub 2008 Jan 8.
Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this review, we summarize our understanding of various factors affecting cell colonization in three-dimensional environment. The structural, biological and degradation properties of the matrix all play key roles during colonization. Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions such as cell adhesion and mechanotransduction also influence colonization.
细胞定殖在多种生物过程和应用中都很重要，包括血管生成、伤口愈合、组织工程、干细胞分化和生物传感器。在定殖过程中，多孔三维结构用于支持和引导细胞向基质内生长。在这篇综述中，我们总结了对影响细胞在三维环境中定殖的各种因素的理解。基质的结构、生物学和降解特性在定殖过程中都起着关键作用。此外，特定的支架特性，如孔隙率、孔径、纤维厚度、形貌和支架刚度，以及重要的细胞与材料相互作用，如细胞黏附与机械转导，也会影响定殖。
