细胞在可降解三维多孔基质中的定植。
Cell colonization in degradable 3D porous matrices.
作者信息
Lawrence Benjamin J, Madihally Sundararajan V
机构信息
School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
出版信息
Cell Adh Migr. 2008 Jan-Mar;2(1):9-16. doi: 10.4161/cam.2.1.5884. Epub 2008 Jan 8.
Abstract
Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this review, we summarize our understanding of various factors affecting cell colonization in three-dimensional environment. The structural, biological and degradation properties of the matrix all play key roles during colonization. Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions such as cell adhesion and mechanotransduction also influence colonization.
摘要
细胞定殖在多种生物过程和应用中都很重要，包括血管生成、伤口愈合、组织工程、干细胞分化和生物传感器。在定殖过程中，多孔三维结构用于支持和引导细胞向基质内生长。在这篇综述中，我们总结了对影响细胞在三维环境中定殖的各种因素的理解。基质的结构、生物学和降解特性在定殖过程中都起着关键作用。此外，特定的支架特性，如孔隙率、孔径、纤维厚度、形貌和支架刚度，以及重要的细胞与材料相互作用，如细胞黏附与机械转导，也会影响定殖。
相似文献
1
Cell colonization in degradable 3D porous matrices.细胞在可降解三维多孔基质中的定植。
Cell Adh Migr. 2008 Jan-Mar;2(1):9-16. doi: 10.4161/cam.2.1.5884. Epub 2008 Jan 8.
2
Colloidal systems toward 3D cell culture scaffolds.胶态体系用于 3D 细胞培养支架。
Adv Colloid Interface Sci. 2020 Sep;283:102237. doi: 10.1016/j.cis.2020.102237. Epub 2020 Aug 8.
3
A porous photocurable elastomer for cell encapsulation and culture.一种用于细胞封装和培养的多孔光固化弹性体。
Biomaterials. 2007 Nov;28(32):4826-35. doi: 10.1016/j.biomaterials.2007.07.039. Epub 2007 Aug 9.
4
The influence of topography on tissue engineering perspective.地形对组织工程学的影响。
Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:906-21. doi: 10.1016/j.msec.2015.12.094. Epub 2016 Jan 2.
5
XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth.XanoMatrix作为间充质干细胞培养和生长的支架材料。
Int J Nanomedicine. 2016 Jun 7;11:2655-61. doi: 10.2147/IJN.S101838. eCollection 2016.
6
Enzyme-degradable phosphorylcholine porous hydrogels cross-linked with polyphosphoesters for cell matrices.用于细胞基质的与聚磷酸酯交联的酶可降解磷酸胆碱多孔水凝胶。
Biomaterials. 2007 Feb;28(6):984-93. doi: 10.1016/j.biomaterials.2006.10.024. Epub 2006 Nov 14.
7
Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs.制备具有孔径梯度的聚合物支架，作为研究组织工程软骨构建体中区域组织的模型。
Tissue Eng. 2005 Sep-Oct;11(9-10):1297-311. doi: 10.1089/ten.2005.11.1297.
8
A novel layer-structured scaffold with large pore sizes suitable for 3D cell culture prepared by near-field electrospinning.一种新型的层状结构支架，具有适合 3D 细胞培养的大孔径，通过近场静电纺丝制备。
Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:18-27. doi: 10.1016/j.msec.2017.12.016. Epub 2017 Dec 15.
9
Influence of porous tantalum scaffold pore size on osteogenesis and osteointegration: A comprehensive study based on 3D-printing technology.多孔钽支架孔径对成骨和骨整合的影响：基于 3D 打印技术的综合研究。
Mater Sci Eng C Mater Biol Appl. 2021 Oct;129:112382. doi: 10.1016/j.msec.2021.112382. Epub 2021 Aug 19.
10
Polymeric scaffolds in tissue engineering: a literature review.组织工程中的聚合物支架：文献综述
J Biomed Mater Res B Appl Biomater. 2017 Feb;105(2):431-459. doi: 10.1002/jbm.b.33547. Epub 2015 Oct 23.
引用本文的文献
1
Advancements and applications of gelatin-based scaffolds in dental engineering: a narrative review.基于明胶的支架在牙科工程中的进展与应用：一项叙述性综述
Odontology. 2025 Jul 17. doi: 10.1007/s10266-025-01155-9.
2
Medicated and multifunctional composite alginate-collagen-hyaluronate based scaffolds prepared using two different crosslinking approaches show potential for healing of chronic wounds.采用两种不同交联方法制备的含药多功能复合藻酸盐-胶原蛋白-透明质酸盐基支架显示出治疗慢性伤口的潜力。
Drug Deliv Transl Res. 2024 Dec 11. doi: 10.1007/s13346-024-01745-0.
3
Nanotechnology in retinal diseases: From disease diagnosis to therapeutic applications.视网膜疾病中的纳米技术：从疾病诊断到治疗应用。
Biophys Rev (Melville). 2024 Nov 5;5(4):041305. doi: 10.1063/5.0214899. eCollection 2024 Dec.
4
Electroactive 4D Porous Scaffold Based on Conducting Polymer as a Responsive and Dynamic Cell Culture Platform.基于导电聚合物的电活性 4D 多孔支架作为响应性和动态细胞培养平台。
ACS Appl Mater Interfaces. 2024 Feb 7;16(5):5613-5626. doi: 10.1021/acsami.3c16686. Epub 2024 Jan 26.
5
Innervation of an Ultrasound-Mediated PVDF-TrFE Scaffold for Skin-Tissue Engineering.用于皮肤组织工程的超声介导聚偏氟乙烯-三氟乙烯共聚物支架的神经支配
Biomimetics (Basel). 2023 Dec 20;9(1):2. doi: 10.3390/biomimetics9010002.
6
The Effect of Chitosan/Alginate/Graphene Oxide Nanocomposites on Proliferation of Mouse Spermatogonial Stem Cells.壳聚糖/海藻酸盐/氧化石墨烯纳米复合材料对小鼠精原干细胞增殖的影响
J Funct Biomater. 2023 Nov 22;14(12):556. doi: 10.3390/jfb14120556.
7
Design and fabrication of a magnetic nanobiocomposite based on flaxseed mucilage hydrogel and silk fibroin for biomedical and in-vitro hyperthermia applications.基于亚麻籽胶水凝胶和丝素蛋白的磁性纳米生物复合材料的设计与制备及其在生物医学和体外热疗中的应用。
Sci Rep. 2023 Nov 27;13(1):20845. doi: 10.1038/s41598-023-46445-w.
8
Microsphere-Enabled Modular Formation of Miniaturized In Vitro Breast Cancer Models.基于微球的模块化方法构建小型化体外乳腺癌模型。
Small. 2024 Apr;20(17):e2307365. doi: 10.1002/smll.202307365. Epub 2023 Nov 21.
9
Polymeric and biological membranes for organ-on-a-chip devices.用于芯片器官装置的聚合物和生物膜。
Microsyst Nanoeng. 2023 Aug 29;9:107. doi: 10.1038/s41378-023-00579-z. eCollection 2023.
10
Recent Advances in the Production of Pharmaceuticals Using Selective Laser Sintering.使用选择性激光烧结技术生产药物的最新进展
Biomimetics (Basel). 2023 Jul 27;8(4):330. doi: 10.3390/biomimetics8040330.
本文引用的文献
1
Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa.具有与小肠黏膜下层相似力学性能的多层复合支架。
J Biomed Mater Res A. 2009 Mar 1;88(3):634-43. doi: 10.1002/jbm.a.31903.
2
The incorporation of poly(lactic-co-glycolic) acid nanoparticles into porcine small intestinal submucosa biomaterials.将聚乳酸-羟基乙酸共聚物纳米颗粒掺入猪小肠黏膜下层生物材料中。
Biomaterials. 2008 Mar;29(9):1159-66. doi: 10.1016/j.biomaterials.2007.11.020.
3
Stem cell differentiation and expansion for clinical applications of tissue engineering.用于组织工程临床应用的干细胞分化与扩增
J Cell Mol Med. 2007 Sep-Oct;11(5):935-44. doi: 10.1111/j.1582-4934.2007.00106.x.
4
The extracellular matrix as a biologic scaffold material.细胞外基质作为一种生物支架材料。
Biomaterials. 2007 Sep;28(25):3587-93. doi: 10.1016/j.biomaterials.2007.04.043. Epub 2007 May 8.
5
Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications.天然来源的聚合物作为生物分子载体和支架用于组织工程应用中的细胞递送。
Adv Drug Deliv Rev. 2007 May 30;59(4-5):207-33. doi: 10.1016/j.addr.2007.03.012. Epub 2007 Apr 6.
6
Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes.组织工程中的血管生成：为构建的组织替代物注入活力。
Tissue Eng. 2006 Aug;12(8):2093-104. doi: 10.1089/ten.2006.12.2093.
7
Bioreactors for tissue engineering.用于组织工程的生物反应器。
Biotechnol Lett. 2006 Sep;28(18):1415-23. doi: 10.1007/s10529-006-9111-x. Epub 2006 Jul 29.
8
Three-dimensional cell colonization in a sulfate rich environment.在富含硫酸盐的环境中的三维细胞定殖。
Biomaterials. 2006 Nov;27(32):5618-26. doi: 10.1016/j.biomaterials.2006.07.006. Epub 2006 Aug 1.
9
Electrospinning of polymeric nanofibers for tissue engineering applications: a review.用于组织工程应用的聚合物纳米纤维静电纺丝：综述
Tissue Eng. 2006 May;12(5):1197-211. doi: 10.1089/ten.2006.12.1197.
10
Cellular mechanotransduction: putting all the pieces together again.细胞机械转导：再次整合所有要素
FASEB J. 2006 May;20(7):811-27. doi: 10.1096/fj.05-5424rev.
Zotero 插件