Arf GTP酶激活蛋白及其在细胞迁移和侵袭中的潜在作用。
Arf GTPase-activating proteins and their potential role in cell migration and invasion.
作者信息
Campa Fanny, Randazzo Paul A
机构信息
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892-4256, USA.
出版信息
Cell Adh Migr. 2008 Oct-Dec;2(4):258-62. doi: 10.4161/cam.2.4.6959. Epub 2008 Oct 9.
Abstract
Cell migration is central to normal physiology in embryogenesis, the inflammatory response and wound healing. In addition, the acquisition of a motile and invasive phenotype is an important step in the development of tumors and metastasis. Arf GTPase-activating proteins (GAPs) are nonredundant regulators of specialized membrane surfaces implicated in cell migration. Part of Arf GAP function is mediated by regulating the ADP ribosylation factor (Arf) family GTP-binding proteins. However, Arf GAPs can also function independently of their GAP enzymatic activity, in some cases working as Arf effectors. In this commentary, we discuss examples of Arf GAPs that function either as regulators of Arfs or independently of the GTPase activity to regulate membrane structures that mediate cell adhesion and movement.
摘要
细胞迁移在胚胎发育、炎症反应和伤口愈合等正常生理过程中至关重要。此外，获得运动性和侵袭性表型是肿瘤发生和转移过程中的重要一步。Arf鸟苷三磷酸酶激活蛋白（GAPs）是参与细胞迁移的特殊膜表面的非冗余调节因子。Arf GAP功能的一部分是通过调节ADP核糖基化因子（Arf）家族的GTP结合蛋白来介导的。然而，Arf GAPs也可以独立于其GAP酶活性发挥作用，在某些情况下作为Arf效应器发挥作用。在本评论中，我们讨论了Arf GAPs的例子，它们要么作为Arfs的调节因子发挥作用，要么独立于GTPase活性来调节介导细胞粘附和运动的膜结构。
相似文献
1
Arf GTPase-activating proteins and their potential role in cell migration and invasion.Arf GTP酶激活蛋白及其在细胞迁移和侵袭中的潜在作用。
Cell Adh Migr. 2008 Oct-Dec;2(4):258-62. doi: 10.4161/cam.2.4.6959. Epub 2008 Oct 9.
2
Arf GAPs as Regulators of the Actin Cytoskeleton-An Update.Arf GAPs 作为细胞骨架肌动蛋白的调节剂——最新进展。
Int J Mol Sci. 2019 Jan 21;20(2):442. doi: 10.3390/ijms20020442.
3
Arf GAPs as regulators of the actin cytoskeleton.作为肌动蛋白细胞骨架调节因子的Arf GAPs
Biol Cell. 2007 Oct;99(10):583-600. doi: 10.1042/bc20070034.
4
Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex.Arf GAPs：一类功能各异但都汇聚于共同结构——整合素黏附复合体的蛋白质家族。
Small GTPases. 2019 Jul;10(4):280-288. doi: 10.1080/21541248.2017.1299271. Epub 2017 Mar 31.
5
Arf GAPs and molecular motors.Arf GAPs与分子马达。
Small GTPases. 2019 May;10(3):196-209. doi: 10.1080/21541248.2017.1308850. Epub 2017 Apr 21.
6
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.ASAP3是一种与粘着斑相关的Arf GAP，在细胞迁移和侵袭中发挥作用。
J Biol Chem. 2008 May 30;283(22):14915-26. doi: 10.1074/jbc.M709717200. Epub 2008 Apr 8.
7
Assays and properties of the Arf GAPs AGAP1, ASAP1, and Arf GAP1.Arf GAPs（AGAP1、ASAP1和Arf GAP1）的检测与特性
Methods Enzymol. 2005;404:147-63. doi: 10.1016/S0076-6879(05)04015-2.
8
Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate.ADP-核糖基化因子 N 端与 GTP 酶激活蛋白 ASAP1 的 PH 结构域的相互作用需要磷脂酰肌醇 4,5-二磷酸。
J Biol Chem. 2019 Nov 15;294(46):17354-17370. doi: 10.1074/jbc.RA119.009269. Epub 2019 Oct 6.
9
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.AZAP 型 Arf GAP 对癌细胞迁移和侵袭的作用。
Adv Cancer Res. 2008;101:1-28. doi: 10.1016/S0065-230X(08)00401-6.
10
A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.一种新的桩蛋白结合蛋白PAG3/Papalpha/KIAA0400，具有ADP核糖基化因子GTP酶激活蛋白活性，参与桩蛋白募集到粘着斑和细胞迁移过程。
Mol Biol Cell. 2000 Apr;11(4):1315-27. doi: 10.1091/mbc.11.4.1315.
引用本文的文献
1
Identify AGAP2 as prognostic biomarker in clear cell renal cell carcinoma based on bioinformatics and IHC staining.基于生物信息学和免疫组化染色，将AGAP2鉴定为透明细胞肾细胞癌的预后生物标志物。
Heliyon. 2023 Feb 5;9(2):e13543. doi: 10.1016/j.heliyon.2023.e13543. eCollection 2023 Feb.
2
The Seminavis robusta genome provides insights into the evolutionary adaptations of benthic diatoms.大角丝藻基因组为底栖硅藻的进化适应提供了见解。
Nat Commun. 2020 Jul 3;11(1):3320. doi: 10.1038/s41467-020-17191-8.
3
Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.源自过表达微小RNA-199a的间充质干细胞的外泌体通过下调AGAP2抑制胶质瘤进展。
Aging (Albany NY). 2019 Aug 5;11(15):5300-5318. doi: 10.18632/aging.102092.
4
Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.小鼠中 ASAP1 的缺失通过失调的 FAK/Src 和 AKT 信号通路损害间充质祖细胞的成脂和成骨分化。
PLoS Genet. 2019 Jun 27;15(6):e1008216. doi: 10.1371/journal.pgen.1008216. eCollection 2019 Jun.
5
Including gene networks to predict calving difficulty in Holstein, Brown Swiss and Jersey cattle.将基因网络纳入荷斯坦、瑞士褐牛和泽西牛的产犊难易度预测中。
BMC Genet. 2018 Apr 2;19(1):20. doi: 10.1186/s12863-018-0606-y.
6
Creutzfeldt-Jakob Disease Subtype-Specific Regional and Temporal Regulation of ADP Ribosylation Factor-1-Dependent Rho/MLC Pathway at Pre-Clinical Stage.克雅氏病亚型特异性区域和时间对临床前期依赖于ADP核糖基化因子1的Rho/肌球蛋白轻链途径的调控
J Mol Neurosci. 2015 Jun;56(2):329-48. doi: 10.1007/s12031-015-0544-3. Epub 2015 Apr 21.
7
Approaches to studying Arf GAPs in cells: in vitro assay with isolated focal adhesions.在细胞中研究Arf GAPs的方法：使用分离的粘着斑进行体外测定。
Curr Protoc Cell Biol. 2012 Jun;Chapter 17:17.13.1-17.13.20. doi: 10.1002/0471143030.cb1713s55.
本文引用的文献
1
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion.AZAP 型 Arf GAP 对癌细胞迁移和侵袭的作用。
Adv Cancer Res. 2008;101:1-28. doi: 10.1016/S0065-230X(08)00401-6.
2
Consensus nomenclature for the human ArfGAP domain-containing proteins.人类含ArfGAP结构域蛋白的共识命名法。
J Cell Biol. 2008 Sep 22;182(6):1039-44. doi: 10.1083/jcb.200806041.
3
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.Arf GTP酶激活蛋白ASAP1与Rab11效应蛋白FIP3相互作用，并调节转铁蛋白受体阳性循环内体的中心体周围定位。
Mol Biol Cell. 2008 Oct;19(10):4224-37. doi: 10.1091/mbc.e08-03-0290. Epub 2008 Aug 6.
4
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.ASAP3是一种与粘着斑相关的Arf GAP，在细胞迁移和侵袭中发挥作用。
J Biol Chem. 2008 May 30;283(22):14915-26. doi: 10.1074/jbc.M709717200. Epub 2008 Apr 8.
5
Src-dependent phosphorylation of ASAP1 regulates podosomes.ASAP1的Src依赖性磷酸化调节足体。
Mol Cell Biol. 2007 Dec;27(23):8271-83. doi: 10.1128/MCB.01781-06. Epub 2007 Sep 24.
6
Arf GAPs as regulators of the actin cytoskeleton.作为肌动蛋白细胞骨架调节因子的Arf GAPs
Biol Cell. 2007 Oct;99(10):583-600. doi: 10.1042/bc20070034.
7
Two human ARFGAPs associated with COP-I-coated vesicles.两种与I型被膜小泡相关的人ARFGAP蛋白。
Traffic. 2007 Nov;8(11):1644-55. doi: 10.1111/j.1600-0854.2007.00631.x. Epub 2007 Sep 29.
8
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.ARAP2对肌动蛋白细胞骨架的影响取决于Arf6特异性鸟苷三磷酸酶激活蛋白活性以及与RhoA - GTP的结合。
J Cell Sci. 2006 Nov 15;119(Pt 22):4650-66. doi: 10.1242/jcs.03237. Epub 2006 Oct 31.
9
Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology.一种新型ADP核糖基化因子GTP酶激活蛋白SMAP参与膜运输：对癌细胞生物学的影响
Cancer Sci. 2006 Sep;97(9):801-6. doi: 10.1111/j.1349-7006.2006.00251.x. Epub 2006 Jun 29.
10
ARF proteins: roles in membrane traffic and beyond.ARF蛋白：在膜泡运输及其他方面的作用
Nat Rev Mol Cell Biol. 2006 May;7(5):347-58. doi: 10.1038/nrm1910.
Zotero 插件