Black D W, Kelly M, Myers C, Noyes R
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Biol Psychiatry. 1990 Feb 1;27(3):319-27. doi: 10.1016/0006-3223(90)90006-n.
The authors evaluated platelet tritiated imipramine binding in 22 outpatients with obsessive-compulsive disorder (OCD) and 22 psychiatrically normal controls matched for age and gender. Mean maximal binding site density (Bmax) and equilibrium dissociation affinity (Kd) values were not significantly different. In OCD patients, Bmax was positively associated with age but was not associated with age of onset, gender, personality disorder, or five measures of illness severity. Eight patients with OCD were subsequently treated with clomipramine up to 300 mg/day for 10 weeks. Among these 8 patients, Bmax values had a 65% mean decrease from baseline, but Bmax values did not change among 7 OCD patients receiving placebo. The results suggest that a reduced density of tritiated imipramine binding sites may not be associated with OCD.
作者评估了22名强迫症（OCD）门诊患者和22名年龄及性别匹配的精神正常对照者的血小板氚化丙咪嗪结合情况。平均最大结合位点密度（Bmax）和平衡解离亲和力（Kd）值无显著差异。在OCD患者中，Bmax与年龄呈正相关，但与发病年龄、性别、人格障碍或五项疾病严重程度指标无关。随后，8名OCD患者接受了最高300毫克/天的氯米帕明治疗，持续10周。在这8名患者中，Bmax值较基线平均下降了65%，但7名接受安慰剂的OCD患者的Bmax值没有变化。结果表明，氚化丙咪嗪结合位点密度降低可能与OCD无关。
