Hu Guo-Xin, Lian Qing-Quan, Ge Ren-Shan, Hardy Dianne O, Li Xiao-Kun
School of Pharmacy, Wenzhou Medical College, Wenzhou 325000, China.
Trends Endocrinol Metab. 2009 Apr;20(3):139-45. doi: 10.1016/j.tem.2008.12.001. Epub 2009 Mar 9.
Phthalates, the most abundantly produced plasticizers, leach out from polyvinyl chloride plastics and disrupt androgen action. Male rats that are exposed to phthalates in utero develop symptoms characteristic of the human condition referred to as testicular dysgenesis syndrome (TDS). Environmental influences have been suspected to contribute to the increasing incidence of TDS in humans (i.e. cryptorchidism and hypospadias in newborn boys and testicular cancer and reduced sperm quality in adult males). In this review, we discuss the recent findings that prenatal exposure to phthalates affects Leydig cell function in the postnatal testis. This review also focuses on the recent progress in our understanding of how Leydig cell factors contribute to phthalate-mediated TDS.
邻苯二甲酸酯是产量最高的增塑剂,会从聚氯乙烯塑料中渗出并干扰雄激素的作用。在子宫内接触邻苯二甲酸酯的雄性大鼠会出现人类所患睾丸发育不全综合征(TDS)的典型症状。人们怀疑环境因素导致了人类TDS发病率的上升(即新生男婴的隐睾症和尿道下裂,以及成年男性的睾丸癌和精子质量下降)。在这篇综述中,我们讨论了近期的研究发现,即产前接触邻苯二甲酸酯会影响出生后睾丸中Leydig细胞的功能。这篇综述还聚焦于我们在理解Leydig细胞因子如何导致邻苯二甲酸酯介导的TDS方面的最新进展。