印度尼西亚禽源和猪源H5N1流感病毒致病性比较
A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia.
作者信息
Takano Ryo, Nidom Chairul A, Kiso Maki, Muramoto Yukiko, Yamada Shinya, Shinya Kyoko, Sakai-Tagawa Yuko, Kawaoka Yoshihiro
机构信息
Department of Microbiology and Immunology, University of Tokyo, Shirokanedai, Minato-ku, Japan.
出版信息
Arch Virol. 2009;154(4):677-81. doi: 10.1007/s00705-009-0353-5. Epub 2009 Mar 14.
Abstract
Highly pathogenic avian influenza H5N1 viruses are circulating in many countries. We recently discovered that these viruses have been transmitted to pigs on multiple occasions in Indonesia. To investigate whether avian H5N1 influenza viruses adapted to mammals through their introduction into pigs, we examined the growth of avian and swine isolates in cell culture and compared their pathogenicity in mice. We found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs. Continuous surveillance of H5N1 viruses among pigs is clearly warranted.
摘要
高致病性H5N1禽流感病毒正在许多国家传播。我们最近发现，这些病毒已多次在印度尼西亚传播给猪。为了调查禽H5N1流感病毒通过引入猪体内是否适应了哺乳动物，我们检测了禽源和猪源分离株在细胞培养中的生长情况，并比较了它们在小鼠体内的致病性。我们发现，猪源分离株对小鼠的毒性低于禽源分离株，这表明病毒在猪体内复制过程中发生了减毒。显然有必要对猪群中的H5N1病毒进行持续监测。
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