Bender J S, Wiencek R G, Bouwman D L
Department of Surgery, Wayne State University, Detroit, Michigan.
Am Surg. 1991 Aug;57(8):536-40; discussion 540-1.
During the period of 1980 to 1986, 49 total abdominal colectomies were performed at the authors' institution for lower gastrointestinal bleeding. The overall mortality was 13 of 49 (27%). In the elective/urgent group, mortality was one of 14 (7%); in the emergency with ileostomy group it was two of two (100%); and in the emergency with anastomosis group it was ten of 33 (30%). Morbidity and mortality in this latter group were affected by age [mortality three of 15 (21%) for age less than 70 vs seven of 18 (37%) for age greater than or equal to 70] and the number of units of blood needed preoperatively and intraoperatively. There was no effect on outcome from type of anastomosis (stapled vs hand-sewn), choice of antibiotics, degree of underlying illness, or day of operation following admission. Thirteen patients had less than 10 units of blood transfused; one (7%) died and there was one complication. Conversely, 20 patients had ten or more blood transfusions and nine (45%) died (P = 0.05 vs former group). This latter group also had 16 major complications, including five anastomotic leaks, three intra-abdominal abscesses, and three myocardial infarctions. Total abdominal colectomy when done as an emergency for colonic hemorrhage is associated with excessive morbidity and mortality rates. An important factor contributing to morbidity and mortality that may be controllable is the amount of blood loss. Should total abdominal colectomy be the surgeon's operation of choice, it should be performed prior to 10 units of blood being needed. If this limit is passed, strong consideration should be given to performance of an ileostomy.
1980年至1986年期间,作者所在机构针对下消化道出血实施了49例全腹结肠切除术。总死亡率为49例中的13例(27%)。在择期/急诊组中,死亡率为14例中的1例(7%);在急诊行回肠造口术组中为2例中的2例(100%);在急诊行吻合术组中为33例中的10例(30%)。后一组的发病率和死亡率受年龄影响(年龄小于70岁者死亡率为15例中的3例,21%;年龄大于或等于70岁者为18例中的7例,37%)以及术前和术中所需输血量。吻合方式(吻合器吻合与手工缝合)、抗生素选择、基础疾病程度或入院后手术日期对结局均无影响。13例患者输血量少于10单位;1例(7%)死亡,有1例并发症。相反,20例患者输血量为10单位或更多,9例(45%)死亡(与前一组相比,P = 0.05)。后一组还有16例严重并发症,包括5例吻合口漏、3例腹腔内脓肿和3例心肌梗死。因结肠出血而急诊行全腹结肠切除术会伴有过高的发病率和死亡率。导致发病率和死亡率的一个重要且可能可控的因素是失血量。如果全腹结肠切除术是外科医生的首选手术,应在需要输血10单位之前进行。如果超过了这个限度,应慎重考虑行回肠造口术。