Ladero Victor, Fernández María, Alvarez Miguel A
Instituto de Productos Lacteos de Asturias, Carretera de Infiesto, Villaviciosa-33300, Spain.
Can J Microbiol. 2009 Feb;55(2):215-8. doi: 10.1139/w08-133.
Lactic acid bacteria (LAB) are recognized as a group of important microorganisms because of their crucial role in food fermentation and their contribution to the maintenance of health homeostasis, as natural inhabitants of the human mucosa. However, the metabolic activities of some strains, such as the ability to synthesize biogenic amines (BAs), can be detrimental to human health. BAs are low molecular weight compounds synthesized by the enzymatic decarboxylation of amino acids. Tyramine, one of the most biologically active BAs, is produced by certain strains of LAB related to food fermentations. Since no data are available as to whether tyramine originates exclusively from food intake, or, like polyamines, could be formed by gut bacteria, this study was focused on the isolation of tyramine-producing LAB from human feces. Different strains of Enterococcus faecium and Enterococcus faecalis able to produce tyramine in culture conditions were isolated.
乳酸菌（LAB）被认为是一类重要的微生物，因为它们在食品发酵中起着关键作用，并且作为人类黏膜的天然寄居菌，对维持健康的体内平衡有重要贡献。然而，某些菌株的代谢活动，如合成生物胺（BAs）的能力，可能对人类健康有害。生物胺是由氨基酸的酶促脱羧作用合成的低分子量化合物。酪胺是最具生物活性的生物胺之一，由与食品发酵相关的某些乳酸菌菌株产生。由于尚无关于酪胺是否仅源于食物摄入，或者是否像多胺一样可由肠道细菌形成的数据，本研究聚焦于从人类粪便中分离产酪胺的乳酸菌。分离出了在培养条件下能够产生酪胺的不同屎肠球菌和粪肠球菌菌株。
