Jahan Ismet Ara, Nahar Nilufar, Mosihuzzaman M, Rokeya Begum, Ali Liaquat, Azad Khan A K, Makhmur Talat, Iqbal Choudhary M
Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh.
Nat Prod Res. 2009;23(4):399-408. doi: 10.1080/14786410802230757.
The effects of Ficus racemosa Linn. fruit extract and fraction on fasting serum glucose levels of normal, type 1 and type 2 diabetic model rats are presented. The aqueous 80% EtOH extract and its water soluble fraction of F. racemosa fruit did not show any serum glucose lowering effect on non-diabetic and type 2 diabetic rats at the fasting condition, whereas the extract showed significant hypoglycaemic effect on the type 1 diabetic model rats. Both the extract and fraction were consistently active in both non-diabetic and types 1 and 2 diabetic model rats when fed simultaneously with glucose load. On the contrary, they were ineffective in lowering blood glucose levels when fed 30 min prior to glucose load. The 1-BuOH soluble part of the ethanol extract exhibited significant antioxidant activity in DPPH free radical scavenging assay. 3-O-(E)-Caffeoyl quinate (1) was isolated for the first time from this plant, which also showed significant antioxidant activity.
本文介绍了聚果榕果实提取物及其馏分对正常、1型和2型糖尿病模型大鼠空腹血清葡萄糖水平的影响。聚果榕果实的80%乙醇水提取物及其水溶性馏分在空腹条件下对非糖尿病和2型糖尿病大鼠未显示出任何降低血清葡萄糖的作用，而该提取物对1型糖尿病模型大鼠显示出显著的降血糖作用。当与葡萄糖负荷同时给药时，提取物和馏分在非糖尿病以及1型和2型糖尿病模型大鼠中均持续发挥作用。相反，在葡萄糖负荷前30分钟给药时，它们在降低血糖水平方面无效。乙醇提取物的正丁醇可溶部分在DPPH自由基清除试验中表现出显著的抗氧化活性。3 - O - (E) - 咖啡酰奎宁酸(1)首次从该植物中分离出来，其也表现出显著的抗氧化活性。
