Yu Shanjiang, Deng Zhiwei, Proksch Peter, Lin Wenhan
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
J Nat Prod. 2006 Sep;69(9):1330-4. doi: 10.1021/np0600494.
Chemical investigation of the marine sponge Haliclona oculata resulted in the isolation of eight new compounds including oculatol (1) and oculatolide (2) and six unusual A-nor steroids, 2-ethoxycarbonyl-2beta-hydroxy-A-nor-ergosta-5,24(28)-dien-4-one (3), 2-ethoxycarbonyl-24-ethyl-2beta-hydroxy-A-nor-cholesta-5-en-4-one (4), 2-ethoxycarbonyl-2beta,7beta-dihydroxy-A-nor-ergosta-5,24(28)-dien-4-one (5), 2-ethoxycarbonyl-2beta,7beta-dihydroxy-A-nor-cholesta-5-en-4-one (6), 2-ethoxycarbonyl-2beta,7beta-dihydroxy-24-methyl-A-nor-cholesta-5,22(E)-dien-4-one (7), and 2-ethoxycarbonyl-2beta,7beta-dihydroxy-A-nor-cholesta-5,22(E)-dien-4-one (8), along with 16 known steroids and indole derivatives. Their structures were unambiguously determined on the basis of extensive spectroscopic analyses.
对海洋海绵Haliclona oculata进行化学研究，结果分离出8种新化合物，包括眼斑醇（1）和眼斑内酯（2）以及6种不寻常的A-去甲甾体化合物，2-乙氧羰基-2β-羟基-A-去甲-麦角甾-5,24(28)-二烯-4-酮（3）、2-乙氧羰基-24-乙基-2β-羟基-A-去甲-胆甾-5-烯-4-酮（4）、2-乙氧羰基-2β,7β-二羟基-A-去甲-麦角甾-5,24(28)-二烯-4-酮（5）、2-乙氧羰基-2β,7β-二羟基-A-去甲-胆甾-5-烯-4-酮（6）、2-乙氧羰基-2β,7β-二羟基-24-甲基-A-去甲-胆甾-5,22(E)-二烯-4-酮（7）以及2-乙氧羰基-2β,7β-二羟基-A-去甲-胆甾-5,22(E)-二烯-4-酮（8），同时还分离出16种已知的甾体化合物和吲哚衍生物。基于广泛的光谱分析明确确定了它们的结构。
