Hjortsjö C, Jonski G, Thrane P S, Saxegaard E, Young A
Department of Prosthodontics, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Caries Res. 2009;43(2):126-31. doi: 10.1159/000209345. Epub 2009 Mar 24.
Acidic fluoride solutions may reduce dental erosion. The aim of this study was to compare the effect of different acidic fluoride solutions on enamel dissolution using an established in vivo model. When possible 4 anterior teeth (255 teeth in a total of 67 subjects) were isolated and exposed to 0.01 M citric acid. The acid was collected in test tubes before (etch I) and 5 min after (etch II) application of test fluoride preparations. Acidic fluoride solutions (pH range 1.5-2.9), i.e. SnF(2), TiF(4) and hydrogen fluoride (HF) (all approx. 0.1 M F), HF (0.027, 0.055, 0.082 M F) and neutral NaF solution (0.1 M F) as control were applied to the labial surfaces of the teeth for 1 min (6 ml/min). Enamel dissolution was examined by chemical analysis of calcium content in the citric acid etch solutions using atom absorption spectrometry. The change in calcium concentration (DeltaCa) and the percentage of mean calcium reduction were calculated from the difference in calcium loss between etch I and etch II. Statistical analysis was carried out using the Wilcoxon signed rank test and Kruskal-Wallis tests with Dunn's multiple comparison. Results showed a mean DeltaCa of 0.671 mg/l (SD 0.625) for SnF(2), and ranged from 0.233 mg/l (SD 0.248) for the weakest HF solution to 0.373 mg/l (SD 0.310) for the strongest HF solution. This represented a 67% reduction in enamel dissolution for SnF(2) and a 40-76% reduction for the HF solutions. No reduction was observed for TiF(4) or NaF. The types of metal, pH and fluoride concentration are all important for the in vivo effect.
酸性氟溶液可能会减少牙齿侵蚀。本研究的目的是使用已建立的体内模型比较不同酸性氟溶液对牙釉质溶解的影响。尽可能隔离4颗前牙（67名受试者共255颗牙齿），并使其暴露于0.01M柠檬酸中。在应用测试氟制剂之前（蚀刻I）和应用后5分钟（蚀刻II），将酸收集在试管中。将酸性氟溶液（pH范围为1.5 - 2.9），即氟化亚锡（SnF₂）、四氟化钛（TiF₄）和氟化氢（HF）（均约为0.1M氟）、HF（0.027、0.055、0.082M氟）和中性氟化钠溶液（0.1M氟）作为对照，以1分钟（6毫升/分钟）的流速施用于牙齿的唇面。通过使用原子吸收光谱法对柠檬酸蚀刻溶液中的钙含量进行化学分析来检查牙釉质溶解情况。根据蚀刻I和蚀刻II之间钙损失的差异计算钙浓度变化（ΔCa）和平均钙减少百分比。使用Wilcoxon符号秩检验和带有邓恩多重比较的Kruskal - Wallis检验进行统计分析。结果显示，SnF₂的平均ΔCa为0.671mg/l（标准差0.625），最弱的HF溶液为0.233mg/l（标准差0.248），最强的HF溶液为0.373mg/l（标准差0.310）。这表明SnF₂使牙釉质溶解减少了67%，HF溶液使牙釉质溶解减少了40 - 76%。未观察到TiF₄或NaF有减少作用。金属类型、pH值和氟浓度对体内效果都很重要。
