Faculty of Dentistry, University of Oslo, Oslo, Norway.
Caries Res. 2013;47(1):2-8. doi: 10.1159/000342619. Epub 2012 Sep 21.
It is not known whether application of fluoride agents on enamel results in lasting resistance to erosive/abrasive wear. We investigated if one daily mouth rinse with sodium fluoride (NaF), stannous fluoride (SnF(2)) or titanium tetrafluoride (TiF(4)) solutions protected enamel against erosive/abrasive wear in situ (a paired, randomised and blind study). Sixteen molars were cut into 4 specimens, each with one amalgam filling (measurement reference surface). Two teeth (2 × 4 specimens) were mounted bilaterally (buccal aspects) on acrylic mandibular appliances and worn for 9 days by 8 volunteers. Every morning, the specimens were brushed manually with water (30 s) extra-orally. Then fluoride solutions (0.4% SnF(2) pH 2.5; 0.15% TiF(4) pH 2.1; 0.2% NaF pH 6.5, all 0.05 M F) were applied (2 min). Three of the specimens from each tooth got different treatment, and the fourth served as control. At midday, the specimens were etched for 2 min in 300 ml fresh 0.01 M hydrochloric acid and rinsed in tap water. This etch procedure was repeated in the afternoon. Topographic measurements were performed by a white-light interferometer. Mean surface loss (±SD) for 16 teeth after 9 days was: SnF(2) 1.8 ± 1.9 µm, TiF(4) 3.1 ± 4.8 µm, NaF 26.3 ± 4.7 µm, control 32.3 ± 4.4 µm. Daily rinse with SnF(2), TiF(4) and NaF resulted in 94, 90 and 18% reduction in enamel erosive/abrasive wear, respectively, compared with control (p < 0.05). The superior protective effect of daily rinse with either stannous or titanium tetrafluoride solutions on erosive/abrasive enamel wear is promising.
目前尚不清楚在牙釉质上应用氟化物是否会产生持久的抗侵蚀/磨损能力。我们研究了每天使用一次氟化钠(NaF),氟化亚锡(SnF₂)或四氟化钛(TiF₄)溶液漱口是否能在体内保护牙釉质免受侵蚀/磨损(配对,随机和盲法研究)。将 16 颗磨牙切成 4 个标本,每个标本均带有一个汞合金填充物(测量参考表面)。两颗牙齿(2×4 个标本)被双侧安装(颊面)在丙烯酸下颌义齿上,并由 8 位志愿者佩戴 9 天。每天早晨,标本在口腔外手动用清水(30 秒)刷牙。然后将氟化物溶液(0.4%SnF₂,pH 2.5;0.15%TiF₄,pH 2.1;0.2%NaF,pH 6.5,均为 0.05 M F)涂在标本上(2 分钟)。每颗牙齿的三个标本接受不同的处理,第四个标本作为对照。中午,将标本在新鲜的 0.01 M 盐酸中蚀刻 2 分钟,并用自来水冲洗。下午重复该蚀刻过程。通过白光干涉仪进行形貌测量。9 天后 16 颗牙齿的平均表面损失(±SD)为:SnF₂ 1.8±1.9 µm,TiF₄ 3.1±4.8 µm,NaF 26.3±4.7 µm,对照 32.3±4.4 µm。与对照组相比,每天用 SnF₂,TiF₄和 NaF 漱口可分别使牙釉质侵蚀/磨损减少 94%,90%和 18%(p<0.05)。每天用氟化亚锡或四氟化钛溶液漱口对牙釉质侵蚀/磨损的保护作用明显优于对照组。