Young Alix, Thrane Per S, Saxegaard Erik, Jonski Grazyna, Rölla Gunnar
Department of Cariology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Eur J Oral Sci. 2006 Jun;114(3):180-3. doi: 10.1111/j.1600-0722.2006.00354.x.
It has recently been shown that stannous fluoride (SnF(2)), in the form of aqueous solutions and as toothpaste, can reduce the dissolution of enamel in erosive acids in vitro and in situ. The aim of this study was to compare the effect of toothpastes containing SnF(2) or NaF on enamel dissolution using an in vivo model. Four healthy anterior teeth in each subject (n = 20) were exposed to diluted citric acid (100 mmol l(-1) or 10 mmol l(-1)) applied using a peristaltic pump (5 ml @7 ml min(-1)) and the acid was collected in a test tube before and after application of the respective toothpastes (etch I and etch II). Toothpaste was applied to the labial surfaces with a soft brush (four applications, each of 1-min duration), with gentle water rinsing between applications. Each subject had one pair of teeth treated with each of the test toothpastes. Enamel dissolution was examined by assessment of calcium content in the citric acid applied before and after the treatment with toothpaste. The results indicate that the SnF(2) toothpaste markedly reduced the dissolution of teeth in vivo (etch II < etch I), whereas the NaF toothpaste provided no protection (etch II > etch I). Toothpaste appears to be an acceptable vehicle for SnF(2) and maintains the dissolution-reducing effect exhibited by aqueous solutions of this fluoride salt.
最近研究表明，氟化亚锡（SnF₂）以水溶液和牙膏的形式，在体外和原位均可减少侵蚀性酸中牙釉质的溶解。本研究的目的是使用体内模型比较含SnF₂或NaF的牙膏对牙釉质溶解的影响。每位受试者（n = 20）的四颗健康前牙暴露于用蠕动泵（5 ml @7 ml min⁻¹）施加的稀释柠檬酸（100 mmol l⁻¹或10 mmol l⁻¹）中，在使用各自牙膏（蚀刻I和蚀刻II）前后，酸被收集在试管中。用软刷将牙膏涂于唇面（涂四次，每次持续1分钟），每次涂抹之间用清水轻轻冲洗。每位受试者的一对牙齿用每种测试牙膏处理。通过评估牙膏处理前后施加的柠檬酸中的钙含量来检查牙釉质溶解情况。结果表明，含SnF₂的牙膏在体内显著减少牙齿溶解（蚀刻II < 蚀刻I），而含NaF的牙膏没有提供保护作用（蚀刻II > 蚀刻I）。牙膏似乎是SnF₂的一种可接受的载体，并保持了该氟化物盐水溶液所表现出的减少溶解的效果。
