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霉菌毒素检测上演“警察与小偷”戏码:环糊精化学传感器堪称专业警察?

Mycotoxin detection plays "cops and robbers": cyclodextrin chemosensors as specialized police?

作者信息

Cozzini Pietro, Ingletto Gianluigi, Singh Ratna, Dall'Asta Chiara

机构信息

Molecular Modeling Laboratory, Department of General and Inorganic Chemistry, University of Parma, Via G.P. Usberti 17/A 43100, Parma, Italy.

INBB, National Institute for Biostructures and Biosystems, Viale Medaglie d'oro 305, 00136 Rome, Italy.

出版信息

Int J Mol Sci. 2008 Dec;9(12):2474-2494. doi: 10.3390/ijms9122474. Epub 2008 Dec 5.

Abstract

As in a cops and robbers play we discover new mycotoxins and metabolites everyday and we are forced to develop new molecules quickly as chemo- or biosensors or to modify existing molecules able to recognize these new hazardous compounds. This will result in an enormous cost saving to agro-food industry through the prevention and reduction of product recalls and reduced treatment costs. Here we present a brief review of the rapid methods used to detect mycotoxins, considering usefulness and limits. Then we propose a new fast, efficient and cheap methodology, based on a combination of computer chemistry aided design and fluorescence, that can help to drive synthesis in a more efficient way.

摘要

就像在一场警察与强盗的游戏中一样,我们每天都会发现新的霉菌毒素和代谢物,因此不得不迅速开发新的分子作为化学或生物传感器,或者对能够识别这些新的有害化合物的现有分子进行改造。这将通过预防和减少产品召回以及降低处理成本,为农业食品行业节省巨额成本。在此,我们简要回顾用于检测霉菌毒素的快速方法,同时考虑其效用和局限性。然后,我们提出一种基于计算机化学辅助设计和荧光相结合的新的快速、高效且廉价的方法,该方法有助于以更高效的方式推动合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef94/2635654/bd5019adb846/ijms-09-02474f1.jpg

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