Cozzini Pietro, Ingletto Gianluigi, Singh Ratna, Dall'Asta Chiara
Molecular Modeling Laboratory, Department of General and Inorganic Chemistry, University of Parma, Via G.P. Usberti 17/A 43100, Parma, Italy.
INBB, National Institute for Biostructures and Biosystems, Viale Medaglie d'oro 305, 00136 Rome, Italy.
Int J Mol Sci. 2008 Dec;9(12):2474-2494. doi: 10.3390/ijms9122474. Epub 2008 Dec 5.
As in a cops and robbers play we discover new mycotoxins and metabolites everyday and we are forced to develop new molecules quickly as chemo- or biosensors or to modify existing molecules able to recognize these new hazardous compounds. This will result in an enormous cost saving to agro-food industry through the prevention and reduction of product recalls and reduced treatment costs. Here we present a brief review of the rapid methods used to detect mycotoxins, considering usefulness and limits. Then we propose a new fast, efficient and cheap methodology, based on a combination of computer chemistry aided design and fluorescence, that can help to drive synthesis in a more efficient way.
就像在一场警察与强盗的游戏中一样,我们每天都会发现新的霉菌毒素和代谢物,因此不得不迅速开发新的分子作为化学或生物传感器,或者对能够识别这些新的有害化合物的现有分子进行改造。这将通过预防和减少产品召回以及降低处理成本,为农业食品行业节省巨额成本。在此,我们简要回顾用于检测霉菌毒素的快速方法,同时考虑其效用和局限性。然后,我们提出一种基于计算机化学辅助设计和荧光相结合的新的快速、高效且廉价的方法,该方法有助于以更高效的方式推动合成。