利用¹³³Xe清除技术研究沙棘和右泛醇-泛昔林对大鼠实验性皮肤烧伤后血流的影响。
Hippophae rhamnoides L. and dexpanthenol-bepanthene on blood flow after experimental skin burns in rats using 133Xe clearance technique.
作者信息
Seven Bedri, Varoglu Erhan, Aktas Omer, Sahin Ali, Gumustekin Kenan, Dane Senol, Suleyman Halis
机构信息
Department of Nuclear Medicine, Ataturk University, Medical School, 25240 Erzurum, Turkey.
出版信息
Hell J Nucl Med. 2009 Jan-Apr;12(1):55-8.
UNLABELLED
The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique.
METHODS
Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique.
RESULTS
HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
未标注
本实验研究的目的是使用氙 - 133（¹³³Xe）清除技术，测定并比较沙棘提取物（HRe - 1）和泛醇对大鼠伤口区域血流的影响。
方法
在大鼠双侧大腿制造烧伤创面，仅在右侧大腿的伤口区域局部应用HRe - 1和泛醇，持续8天。在局部应用HRe - 1和泛醇前后，使用¹³³Xe清除技术评估它们对伤口区域血流的影响。
结果
HRe - 1显著增加了伤口区域的血流（P<0.05）。泛醇使血流增加的幅度较小。总之，我们在大鼠身上的研究结果表明，HRe - 1可增加伤口区域的血流，并且可用于治疗皮肤伤口愈合，优于泛醇。
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