Seven Bedri, Varoglu Erhan, Aktas Omer, Sahin Ali, Gumustekin Kenan, Dane Senol, Suleyman Halis
Department of Nuclear Medicine, Ataturk University, Medical School, 25240 Erzurum, Turkey.
Hell J Nucl Med. 2009 Jan-Apr;12(1):55-8.
The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique.
Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique.
HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
本实验研究的目的是使用氙 - 133（¹³³Xe）清除技术，测定并比较沙棘提取物（HRe - 1）和泛醇对大鼠伤口区域血流的影响。
在大鼠双侧大腿制造烧伤创面，仅在右侧大腿的伤口区域局部应用HRe - 1和泛醇，持续8天。在局部应用HRe - 1和泛醇前后，使用¹³³Xe清除技术评估它们对伤口区域血流的影响。
HRe - 1显著增加了伤口区域的血流（P<0.05）。泛醇使血流增加的幅度较小。总之，我们在大鼠身上的研究结果表明，HRe - 1可增加伤口区域的血流，并且可用于治疗皮肤伤口愈合，优于泛醇。
