右泛醇与神经酰胺组合物对大鼠皮肤烧伤创面治疗效果的组织学评价

HISTOLOGICAL EVALUATION OF THERAPEUTIC EFFECTS OF DEXPANTHENOL COMPOSITION WITH CERAMIDES IN RATS WITH SKIN BURN INJURY.

作者信息

Butko Ya, Ulanova V, Tkacheva O, Mishchenko O

机构信息

The National University of Pharmacy; Institute of qualification improvement for pharmacists of The National University of Pharmacy, Kharkiv, Ukraine.

出版信息

Georgian Med News. 2018 Sep(282):134-139.

PMID:30358557

Abstract

The objective of our research was histological evaluation of therapeutic effects in case of burn injury in rats. Experiment was conducted on 84 test rats with burn injury of III-A stage. Therapeutical effect of studied medicines was evaluated using histological methods. Results achived gave evidence that on 18-th day of treatment with ceremids cream and dexpanthenol with ceramids cream the level granulation tissue maturing increased by 1,4 and 1,7 times and intensity of burn injury epithelization rose by 1,5 and 1,9 times in comparison with non-treated animals. Therapeutic effect of dexpanthenol with ceramids cream significantly overcome action of «Bepanten» cream. Thus, experiment done proved efficiency of ceramids use in cream composition with dexpanthenol as one of the therapeutic methods aimed at increase of skin burn injury healing activation.

摘要

我们研究的目的是对大鼠烧伤的治疗效果进行组织学评估。实验在84只III-A期烧伤的试验大鼠上进行。使用组织学方法评估所研究药物的治疗效果。所获得的结果表明，与未治疗的动物相比，在用神经酰胺乳膏和泛醇神经酰胺乳膏治疗的第18天，肉芽组织成熟水平分别提高了1.4倍和1.7倍，烧伤创面上皮化强度分别提高了1.5倍和1.9倍。泛醇神经酰胺乳膏的治疗效果明显优于“拜普洛”乳膏。因此，所做的实验证明了将神经酰胺与泛醇一起用于乳膏组合物中作为旨在促进皮肤烧伤愈合的治疗方法之一的有效性。