Toda Reiko, Hoshino Tomoaki, Kawayama Tomotaka, Imaoka Haruki, Sakazaki Yuki, Tsuda Toru, Takada Shohei, Kinoshita Masaharu, Iwanaga Tomoaki, Aizawa Hisamichi
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume.
Intern Med. 2009;48(7):513-21. doi: 10.2169/internalmedicine.48.1781. Epub 2009 Apr 1.
The concept of "lung age" is thought to be useful for understanding pulmonary function. In this study, we validated "lung age" to detect pulmonary function abnormalities in pulmonary diseases.
We used both spirometry and an electronic FEV(1)/FEV(6) meter (FEV(6) meter) to perform pulmonary function tests. We evaluated the sensitivity and specificity of FEV(6) and FEV(1)/FEV(6), and calculated "lung age" in Japanese subjects including those with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), and interstitial lung diseases (ILD).
FEV(1) (spirometer) vs. FEV(1) (FEV(6) meter), FVC (spirometer) vs. FEV(6) (FEV(6) meter), and FEV(1)/FVC (spirometer) vs. FEV(1)/FEV(6) (FEV(6) meter) measurements were all significantly and closely correlated. For the difference of "lung age" and "actual age", the area under the receiver operating characteristic curve (ROC-AUC) for detecting obstructive impairment was 0.807 (spirometer) and 0.772 (FEV(6) meter), respectively. The corresponding ROC-AUC for detecting restrictive impairment was 0.891 and 0.836, respectively, and that for detecting both obstructive and restrictive impairment was 0.918 and 0.853, respectively. For detection of both obstructive and restrictive impairment, the difference of the "lung age" and "actual age" cut-off value, corresponding to the greatest sum of sensitivity and specificity, was 18.3 years (spirometer) and 19.8 years (FEV(6) meter), respectively. The sensitivity was 0.783 (spirometer) and 0.801 (FEV(6) meter), and the specificity was 0.895 (spirometer) and 0.790 (FEV(6) meter), respectively.
"Lung age" can provide an easy interpretation of the results, and can detect pulmonary function abnormalities in pulmonary diseases.
“肺龄”这一概念被认为有助于理解肺功能。在本研究中，我们验证了“肺龄”在检测肺部疾病肺功能异常方面的作用。
我们使用肺活量测定法和电子FEV(1)/FEV(6)测量仪（FEV(6)测量仪）进行肺功能测试。我们评估了FEV(6)和FEV(1)/FEV(6)的敏感性和特异性，并计算了包括慢性阻塞性肺疾病（COPD）、支气管哮喘（BA）和间质性肺疾病（ILD）患者在内的日本受试者的“肺龄”。
FEV(1)（肺活量测定仪）与FEV(1)（FEV(6)测量仪）、FVC（肺活量测定仪）与FEV(6)（FEV(6)测量仪）以及FEV(1)/FVC（肺活量测定仪）与FEV(1)/FEV(6)（FEV(6)测量仪）的测量结果均显著且密切相关。对于“肺龄”与“实际年龄”的差异，检测阻塞性损伤的受试者工作特征曲线下面积（ROC-AUC）分别为0.807（肺活量测定仪）和0.772（FEV(6)测量仪）。检测限制性损伤的相应ROC-AUC分别为0.891和0.836，检测阻塞性和限制性损伤的ROC-AUC分别为0.918和0.853。对于检测阻塞性和限制性损伤，“肺龄”与“实际年龄”的截断值差异（对应最大敏感性和特异性之和）分别为18.3岁（肺活量测定仪）和19.8岁（FEV(6)测量仪）。敏感性分别为0.783（肺活量测定仪）和0.801（FEV(6)测量仪），特异性分别为0.895（肺活量测定仪）和0.790（FEV(6)测量仪）。
“肺龄”能够对结果进行简单解读，并可检测肺部疾病中的肺功能异常。
