Hager H A, Bader D M
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232-6300, USA.
Histol Histopathol. 2009 Jun;24(6):777-87. doi: 10.14670/HH-24.777.
Bves was discovered in 1999 by two independent laboratories using screens to identify novel genes that were highly expressed in the developing heart (Reese et al., 1999; Andree et al., 2000). As an evolutionarily conserved transmembrane protein, Bves is postulated to play a role in cell adhesion and cell motility. In studies of Bves protein disruption, there have been multiple phenotypes, but few molecular mechanisms have been advanced to explain the underlying cause of these phenotypes. As the molecular function of Bves protein begins to be uncovered, it is now time to review the literature to examine the significance of this work and future directions of study. This review summarizes the literature on this unique protein and explores new and exciting data that support emerging themes on its molecular function.
1999年，两个独立的实验室通过筛选在发育中的心脏中高表达的新基因，发现了Bves（里斯等人，1999年；安德烈等人，2000年）。作为一种进化上保守的跨膜蛋白，Bves被推测在细胞黏附和细胞运动中发挥作用。在对Bves蛋白破坏的研究中，出现了多种表型，但很少有分子机制被提出来解释这些表型的潜在原因。随着Bves蛋白的分子功能开始被揭示，现在是时候回顾文献，审视这项工作的意义以及未来的研究方向了。这篇综述总结了关于这种独特蛋白质的文献，并探索了支持其分子功能新出现主题的令人兴奋的新数据。
