Behavioral Neuroscience Division, Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35394-1170, USA.
Int J Obes (Lond). 2009 Jun;33(6):693-701. doi: 10.1038/ijo.2009.57. Epub 2009 Apr 7.
Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have the power to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten.
Rats were conditioned to associate intake of Oreo cookies as the PF to cages with distinct context cues that differed from cues in cages where they were only given chow. PF naturally stimulated greater caloric intake. The rats were then tested in the PF cage with only chow available to determine whether the PF-paired cues, alone, could elicit overeating of plain chow.
Non-food-deprived female Sprague-Dawley rats.
Intake of plain chow under PF-paired cues vs chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect of binge-prone vs binge-resistant status to predict cued-overeating.
Rats consumed significantly more chow when exposed to context cues paired earlier with PF than with chow (P<0.01). This effect occurred using various cues (for example, different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (P<0.001) and was unaffected by baseline differences in propensity to binge on PF.
Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of a PF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity.
在肥胖症治疗中，暴食复发是一个顽固的问题。我们检验了这样一个假设，即美味食物（PF）摄入的环境线索即使是在不太 PF 的情况下也有能力破坏热量调节。环境线索是非食物线索，存在于习惯性食用 PF 的环境中。
大鼠被训练将 Oreo 饼干作为 PF 与具有独特环境线索的笼子联系起来，这些线索与它们只被给予饲料的笼子中的线索不同。PF 自然会刺激更大的热量摄入。然后，这些大鼠在仅提供 PF 的 PF 笼子中进行测试，以确定 PF 配对的线索是否单独可以引起对普通 PF 的过度进食。
非饥饿剥夺的雌性 Sprague-Dawley 大鼠。
在 PF 配对线索下与在 PF 配对线索下的普通 PF 摄入量进行比较。这也在包括 PF 小块作为启动刺激的测试中进行了测量。我们还控制了易暴食与不易暴食状态的任何影响，以预测线索性暴食。
与用饲料配对的线索相比，暴露于与 PF 早些时候配对的环境线索时，大鼠消耗的普通 PF 明显更多（P<0.01）。这种效果使用各种线索（例如，不同类型的床上用品或壁纸）都出现了。PF 小块的启动作用使效果加强（P<0.001），并且不受基线对 PF 暴食倾向的差异影响。
与 PF 摄入相关的环境线索甚至可以驱动对较少 PF 的过度进食，并消除大鼠补偿 PF 启动器卡路里的能力。正如与药物相关的环境线索可以重新引发药物成瘾复发一样，PF 配对线索可能会引发与体重恢复和肥胖相关的过度进食复发。该模型应有助于确定破坏坚持健康低热量饮食计划的反射样生物学，并更关注治疗暴食和肥胖症中的线索因素。
